Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Hexadimethrine bromide
Price:
Purity: 95.0%
Stocking Period: 10 Day
Contact: Huang

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Hexadimethrine bromide
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

DC Chemicals Limited
China
Product Name: Hexadimethrine bromide (1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide)
Price: $100.0/100mg $200.0/250mg $400.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Poly[(dimethyliminio)-1,3-propanediyl(dimethyliminio)-1,6-hexanediylbromide (1:2)]
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

28728-55-4

28728-55-4 structure

28728-55-4 structure

Name: Hexadimethrine bromide
Chemical Name: Sequa-brene
CAS Number: 28728-55-4
Molecular Formula: C₁₅H₃₆Br₂N₂
Molecular Weight: 404.27
Catalog: Research Areas Cancer
Create Date: 2018-03-09 08:00:00
Modify Date: 2024-01-02 17:29:02
Hexadimethrine bromide is a cationic polymer discovered to enhance retroviral transduction.

Name	Sequa-brene
Synonyms	Hexadimethrine bromide,Polybrene HEXADIMETHRINE BROMIDE 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide,Polybrene MFCD00133397

Description	Hexadimethrine bromide is a cationic polymer discovered to enhance retroviral transduction.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
In Vitro	Hexadimethrine bromide inhibits human mesenchymal stem cell proliferation during lentiviral transduction. Hexadimethrine bromide is considered non-toxic at low concentrations, but has been found to negatively affect cell proliferation in some cell types at concentrations greater than 10 µg/mL. Trypsinized cells exposed to Hexadimethrine bromide are visibly larger in size when viewed under the microscope[1].
Cell Assay	Trypsinized cells are washed and resuspended in medium at 2×104 cells/mL with or without rhFGF-2 (final concentration=10 ng/mL, PeproTech) and with or without Hexadimethrine bromide at a final Hexadimethrine bromide concentration of 1, 4, or 8 µg/mL. The different conditions are seeded in 96-well plates at 1×103 cells in 50 µL per well in triplicate and cultured at 37°C, 5% CO2. After 6, 9, or 24 hr, the medium is changed and subsequent medium changes occurred every 3-4 days with 50 µL of ± FGF-2 medium (10 ng/mL). Plates are harvested on day 4, 7, 14, and 21 by removing the medium and placing the plates in the -80°C freezer until the day of analysis. The CyQUANT assay is then performed on the wells[1].
References	[1]. Lin P, et al. Polybrene inhibits human mesenchymal stem cell proliferation during lentiviral transduction. PLoS One. 2011;6(8):e23891.

Boiling Point	209.5ºC at 760 mmHg
Molecular Formula	C₁₅H₃₆Br₂N₂
Molecular Weight	404.27
Flash Point	73.9ºC
Vapour Pressure	0.202mmHg at 25°C
Storage condition	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TQ2655000

CHEMICAL NAME :: Poly((dimethyliminio)hexamethylene(dimethylimino)trim ethylene dibromide)

CAS REGISTRY NUMBER :: 28728-55-4

LAST UPDATED :: 199703

DATA ITEMS CITED :: 4

WISWESSER LINE NOTATION :: /E3E &1N1&5N1&1/

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4013507

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4013507

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 37,267,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4013507

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn: Harmful;
Risk Phrases	R20/21/22
RIDADR	UN 2811
RTECS	TQ2655000
Packaging Group	III
Hazard Class	6.1(b)