2098211-50-6
2098211-50-6 structure
- Name: I-138
- Chemical Name: I-138
- CAS Number: 2098211-50-6
- Molecular Formula: C26H23F3N6O
- Molecular Weight: 492.50
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Deubiquitinase
- Create Date: 2023-07-19 18:15:54
- Modify Date: 2024-01-07 18:44:32
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I-138 is an orally active compound structurally related to ML323 (HY-17543). I-138 and ML-323 are potent reversible inhibitors of USP1-UAF1. I-138 displays synergistic binding with ubiquitin and mutual exclusive binding with ML323. I-138 induces the monoubiquitination of FANCD2 and PCNA in MDA-MB-436 cells, increases PCNA and FANCD2 monoubiquitination in HAP-1 USP1 WT cells. I-138 ablates USP1 autocleavage in cells[1].
| Name | I-138 |
|---|
| Description | I-138 is an orally active compound structurally related to ML323 (HY-17543). I-138 and ML-323 are potent reversible inhibitors of USP1-UAF1. I-138 displays synergistic binding with ubiquitin and mutual exclusive binding with ML323. I-138 induces the monoubiquitination of FANCD2 and PCNA in MDA-MB-436 cells, increases PCNA and FANCD2 monoubiquitination in HAP-1 USP1 WT cells. I-138 ablates USP1 autocleavage in cells[1]. |
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| Molecular Formula | C26H23F3N6O |
|---|---|
| Molecular Weight | 492.50 |