2864408-92-2

2864408-92-2 structure

Name: GBD-9
Chemical Name: GBD-9
CAS Number: 2864408-92-2
Molecular Formula: C₄₄H₄₇N₉O₆
Molecular Weight: 797.90
Catalog: Signaling Pathways PROTAC PROTAC
Create Date: 2023-09-29 16:42:02
Modify Date: 2024-01-04 02:15:17
GBD-9 is a double-mechanism degrader that efficiently degrades BTK and GSPT1 by recruiting the E3 ligase cereblon (CRBN). GBD-9 acts both as a PROTAC molecule to induce the degradation of BTK and as a molecular glue to degrade GSPT1. GBD-9 effectively inhibits cancer cell growth[1].

Name	GBD-9

Description	GBD-9 is a double-mechanism degrader that efficiently degrades BTK and GSPT1 by recruiting the E3 ligase cereblon (CRBN). GBD-9 acts both as a PROTAC molecule to induce the degradation of BTK and as a molecular glue to degrade GSPT1. GBD-9 effectively inhibits cancer cell growth[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk Signaling Pathways >> PROTAC >> PROTAC
Target	Cereblon
References	[1]. Zimo Yang, et al. Merging PROTAC and molecular glue for degrading BTK and GSPT1 proteins concurrently. Cell Res. 2021 Dec;31(12):1315-1318.

Molecular Formula	C₄₄H₄₇N₉O₆
Molecular Weight	797.90