GBD-9

Modify Date: 2024-01-04 02:15:17

GBD-9 structure	Common Name	GBD-9
	CAS Number	2864408-92-2	Molecular Weight	797.90
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₄H₄₇N₉O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of GBD-9

GBD-9 is a double-mechanism degrader that efficiently degrades BTK and GSPT1 by recruiting the E3 ligase cereblon (CRBN). GBD-9 acts both as a PROTAC molecule to induce the degradation of BTK and as a molecular glue to degrade GSPT1. GBD-9 effectively inhibits cancer cell growth[1].

Name	GBD-9

Description	GBD-9 is a double-mechanism degrader that efficiently degrades BTK and GSPT1 by recruiting the E3 ligase cereblon (CRBN). GBD-9 acts both as a PROTAC molecule to induce the degradation of BTK and as a molecular glue to degrade GSPT1. GBD-9 effectively inhibits cancer cell growth[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk Signaling Pathways >> PROTAC >> PROTAC
Target	Cereblon
References	[1]. Zimo Yang, et al. Merging PROTAC and molecular glue for degrading BTK and GSPT1 proteins concurrently. Cell Res. 2021 Dec;31(12):1315-1318.

Molecular Formula	C₄₄H₄₇N₉O₆
Molecular Weight	797.90

GBD-9

Use of GBD-9

Names

GBD-9 Biological Activity

Chemical & Physical Properties