1835666-87-9

1835666-87-9 structure

Name: EGFR-IN-87
Chemical Name: EGFR-IN-87
CAS Number: 1835666-87-9
Molecular Formula: C₂₈H₃₃N₇O₂
Molecular Weight: 499.61
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2023-10-29 01:01:12
Modify Date: 2024-01-29 17:20:14
EGFR-IN-87 is a EGFR tyrosine kinase inhibitor. EGFR-IN-87 has IC50 value of 3.1 nM, 1.3 nM and 7.1 nM for EGFR_d746-750, EGFR_L858R/T790 and EGFR_WT in A431 cells, respectively. EGFR-IN-87 can be used for cancer diseases research[1].

Name	EGFR-IN-87

Description	EGFR-IN-87 is a EGFR tyrosine kinase inhibitor. EGFR-IN-87 has IC50 value of 3.1 nM, 1.3 nM and 7.1 nM for EGFR_d746-750, EGFR_L858R/T790 and EGFR_WT in A431 cells, respectively. EGFR-IN-87 can be used for cancer diseases research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFR tyrosine kinase inhibitor for treatment of cancer， IC50 for EGFR d746~750, EGFR L858R/T790, EGFR WT was in nanomolar level.；WO2017120429（Example 2）；陈婷婷要求上线，2023/9/15
References	[1]. Song Y.T, et al. Selective inhibitors of clinically important mutants of the egfr tyrosine kinase. The United States, WO2017120429 A1. 2017-07-13.

Molecular Formula	C₂₈H₃₃N₇O₂
Molecular Weight	499.61