2920046-95-1

2920046-95-1 structure

Name: HDAC-IN-63
Chemical Name: HDAC-IN-63
CAS Number: 2920046-95-1
Molecular Formula: C₂₅H₂₆Cl₂N₆O₃
Molecular Weight: 529.42
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2024-09-18 19:59:41
Modify Date: 2024-09-18 19:59:41
HDAC-IN-63 (Compound 63) is a dual FLT3/HDAC inhibitor (IC50: 0.844 and 30.0 nM for FLT3 and HDAC1 respectively). HDAC-IN-63 inhibits MV4-11 cell proliferation (IC50: 92 nM. HDAC-IN-63 induces apoptosis and arrests cell cycle in MV4-11 cells. HDAC-IN-63 can be used for research of acute myeloid leukemia (AML)[1].

Name	HDAC-IN-63

Description	HDAC-IN-63 (Compound 63) is a dual FLT3/HDAC inhibitor (IC50: 0.844 and 30.0 nM for FLT3 and HDAC1 respectively). HDAC-IN-63 inhibits MV4-11 cell proliferation (IC50: 92 nM. HDAC-IN-63 induces apoptosis and arrests cell cycle in MV4-11 cells. HDAC-IN-63 can be used for research of acute myeloid leukemia (AML)[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3 Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	0.844 and 30.0 nM for FLT3 and HDAC1[1]
References	[1]. Wang Z, et al. Rational discovery of dual FLT3/HDAC inhibitors as a potential AML therapy. Eur J Med Chem. 2023 Aug 28;260:115759.

Molecular Formula	C₂₅H₂₆Cl₂N₆O₃
Molecular Weight	529.42