4896-76-8
4896-76-8 structure
- Name: (N,N,O-2H3)Glycine
- Chemical Name: deuterio 2-(dideuterioamino)acetate
- CAS Number: 4896-76-8
- Molecular Formula: C2H2D3NO2
- Molecular Weight: 78.09
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
- Create Date: 2018-09-09 18:24:00
- Modify Date: 2024-01-09 08:38:00
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Glycine-d3 is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
| Name | deuterio 2-(dideuterioamino)acetate |
|---|---|
| Synonyms |
N,N,O-trideuterio-glycine
N,N,1-Trideutero-glycin Glycine-N,N,1-d glycine-N,N,O-d3 N,N,O-Trideuterio-glycin N,N,O-d3-glycine (N,N,O-H)Glycine MFCD00074933 |
| Description | Glycine-d3 is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. |
|---|---|
| Related Catalog | |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 240.9±23.0 °C at 760 mmHg |
| Melting Point | 240ºC (dec.)(lit.) |
| Molecular Formula | C2H2D3NO2 |
| Molecular Weight | 78.09 |
| Flash Point | 99.5±22.6 °C |
| Exact Mass | 78.050858 |
| PSA | 63.32000 |
| LogP | -1.03 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.461 |
| RIDADR | NONH for all modes of transport |
|---|
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4896-76-8 |
| Literature: Mueller, Carmen; Schajor, W.; Zimmermann, H.; Haeberlen, U. Journal of Magnetic Resonance (1969-1992), 1984 , vol. 56, # 2 p. 235 - 246 |
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4896-76-8 |
| Literature: Crugeiras, Juan; Rios, Ana; Riveiros, Enrique; Richard, John P. Journal of the American Chemical Society, 2011 , vol. 133, # 9 p. 3173 - 3183 |
