2489672-09-3

2489672-09-3 structure

Name: EZH2-IN-17
Chemical Name: EZH2-IN-17
CAS Number: 2489672-09-3
Molecular Formula: C₃₆H₄₆N₄O₄
Molecular Weight: 598.77
Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
Create Date: 2024-01-20 19:30:38
Modify Date: 2024-01-20 19:30:38
EZH2-IN-17 (compound 28) is a potent and orally active EZH2 inhibitor with an IC50 value of 0.95 nM. EZH2-IN-17 exhibits high anti-proliferation activity against different lymphoma cell lines including WSU-DLCL2, Pfeiffer and Karpas-422 (IC50 values of 2.36 nM, 1.73 nM, and 1.82 nM, respectively)[1].

Name	EZH2-IN-17

Description	EZH2-IN-17 (compound 28) is a potent and orally active EZH2 inhibitor with an IC50 value of 0.95 nM. EZH2-IN-17 exhibits high anti-proliferation activity against different lymphoma cell lines including WSU-DLCL2, Pfeiffer and Karpas-422 (IC50 values of 2.36 nM, 1.73 nM, and 1.82 nM, respectively)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase
References	[1]. Xin Xu, et al. Conformationally constrained potent inhibitors for enhancer of zeste homolog 2 (EZH2). Bioorg Med Chem Lett. 2023 Nov 11:129558.

Molecular Formula	C₃₆H₄₆N₄O₄
Molecular Weight	598.77