2987905-95-1

2987905-95-1 structure

Name: HDAC1/CDK7-IN-1
Chemical Name: HDAC1/CDK7-IN-1
CAS Number: 2987905-95-1
Molecular Formula: C₃₃H₃₂ClN₇O₄
Molecular Weight: 626.10
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2023-12-27 18:01:43
Modify Date: 2024-01-09 13:19:00
HDAC1/CDK7-IN-1 (compound 8e) is a dual CDK7 and HDAC1 inhibitor with IC50s of 893 nM and 248 nM, respectively. HDAC1/CDK7-IN-1 inhibits the growth cells of MDA-MB-231, MCF-7, A549, and HCT-116 cancer cells. HDAC1/CDK7-IN-1 induces cell cycle arrest and apoptosis in HCT-116 cells, as well as hindered the migration of HCT-116 cells[1].

Name	HDAC1/CDK7-IN-1

Description	HDAC1/CDK7-IN-1 (compound 8e) is a dual CDK7 and HDAC1 inhibitor with IC50s of 893 nM and 248 nM, respectively. HDAC1/CDK7-IN-1 inhibits the growth cells of MDA-MB-231, MCF-7, A549, and HCT-116 cancer cells. HDAC1/CDK7-IN-1 induces cell cycle arrest and apoptosis in HCT-116 cells, as well as hindered the migration of HCT-116 cells[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	CDK7:893 nM (IC50) HDAC1:248 nM (IC50)
References	[1]. Yao Chen, et al. Discovery of a Dual-Target Inhibitor of CDK7 and HDAC1 That Induces Apoptosis and Inhibits Migration in Colorectal Cancer. ChemMedChem. 2023 Oct 11:e202300281.

Molecular Formula	C₃₃H₃₂ClN₇O₄
Molecular Weight	626.10