Name | 2-methylthioadenosine 5-monophosphate |
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Synonyms |
2-methylthioadenosine 5'-monophosphate triethylammonium salt hydrate
2-MeSAMP,2-Methylthio-AMP hydrate triethylammonium salt 2-Methylthio-AMP 2-mesamp 2,6,2',6'-TETRAMETHYLAZOBENZENE NN'-DIOXIDE---CRYSTALLINE 2-methylthioadenosine-5'-monophosphate |
Description | 2-Methylthio-AMP (2-MeSAMP) is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP is an inhibitor of ADP-dependent platelet aggregation[1][2][3]. |
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Related Catalog | |
Target |
P2Y12[1] |
In Vitro | 2-Methylthio-AMP (2-MeSAMP) inhibits agonist-mediated αIIbβ3 activation in platelets[1]. 2-methylthio-AMP (50 μM; for 5 minutes) does not significantly inhibit thrombin, PAR1-AP, PAR4-AP, or ADP-mediated platelet Ca2+ mobilization. 2-methylthio-AMP fails to inhibit Ca2+ mobilization in P2Y12-deficient mouse platelets and does not raise cAMP or induce vasodilator-stimulated phosphoprotein phosphorylation in wild-type platelets[1]. |
References |
Molecular Formula | C11H16N5O7PS |
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Molecular Weight | 393.31300 |
Exact Mass | 393.05100 |
PSA | 221.18000 |