Name | 5-[[4-(dimethylamino)-3,5-dimethoxyphenyl]methyl]pyrimidine-2,4-diamine |
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Synonyms |
Aditoprima
Aditoprim Aditoprime |
Description | Aditoprime (Aditoprim), a selective bacterial dihydrofolate reductase (DHFR) inhibitor, inhibits the transformation of dihydrofolic acid to tetrahydrofolic acid. Aditoprime inhibits E.coli and L.casei DHFR with IC50 of 47 and 520 nM, respectively. Aditoprime has a broad antimicrobial spectrum, good antibacterial activity and excellent pharmacokinetics[1][2][3]. |
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Related Catalog | |
In Vitro | Aditoprime has the same antibacterial spectrum as TMP. Salmonellaand Streptococcus from swine, E. coli and Salmonella from chickens, E. coli, Streptococcus, Mannheimia, and Pasteurella from calves, Streptococcus and Mannheimia from sheep, and E. coli, Flavobacterium columnare, A. baumannii and Y. ruckeri from fishes are highly susceptible to Aditoprime (MIC or MIC50 ≤ 4 μg/mL)[1]. |
In Vivo | Aditoprime (Aditoprim) has longer elimination half-lives (3.3~14.8 h) and higher distribution volumes (4.6~10.4 L/kg) than those of Trimethoprim (TMP) in pig, calf, monkey, sheep and some other animal species, and a similar pattern is observed for Aditoprime where the distribution volume is about four times higher than that of TMP[1]. Aditoprime (10 -40 mg/kg; b.w.; intramuscularly) shows efficacy in infected swine (swine streptococcosis)[1]. |
References |
Density | 1.233g/cm3 |
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Boiling Point | 503.9ºC at 760 mmHg |
Molecular Formula | C15H21N5O2 |
Molecular Weight | 303.36000 |
Flash Point | 258.5ºC |
Exact Mass | 303.17000 |
PSA | 100.98000 |
LogP | 1.17520 |
Index of Refraction | 1.633 |
Hazard Codes | Xi |
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~% 56066-63-8 |
Literature: Hoffmann-La Roche Inc. Patent: US4515948 A1, 1985 ; |
Precursor 2 | |
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DownStream 0 |