223488-57-1
223488-57-1 structure
- Name: Evatanepag
- Chemical Name: 2-[3-[[(4-tert-butylphenyl)methyl-pyridin-3-ylsulfonylamino]methyl]phenoxy]acetic acid
- CAS Number: 223488-57-1
- Molecular Formula: C25H28N2O5S
- Molecular Weight: 468.565
- Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Benzylpyridine
- Create Date: 2018-12-01 13:01:56
- Modify Date: 2024-01-20 22:02:27
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Evatanepag (CP-533536) is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM.IC50 value: 0.3 nM (EC50)Target PGE2in vitro: CP-533536 is a potent and selective EP2agonist. CP-533536 demonstrates the ability to heal fractures when administered locally as a single dose in rat models of fracture healing. CP-533536 demonstrates excellent in vitro potency against EP2 and selectivity against a broad panel of other targets.
| Name | 2-[3-[[(4-tert-butylphenyl)methyl-pyridin-3-ylsulfonylamino]methyl]phenoxy]acetic acid |
|---|---|
| Synonyms |
CP-533536
UNII-L266R6E31E [3-({[4-(2-Methyl-2-propanyl)benzyl](3-pyridinylsulfonyl)amino}methyl)phenoxy]acetic acid Acetic acid, 2-[3-[[[[4-(1,1-dimethylethyl)phenyl]methyl](3-pyridinylsulfonyl)amino]methyl]phenoxy]- evatanepag CP533536 |
| Description | Evatanepag (CP-533536) is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM.IC50 value: 0.3 nM (EC50)Target PGE2in vitro: CP-533536 is a potent and selective EP2agonist. CP-533536 demonstrates the ability to heal fractures when administered locally as a single dose in rat models of fracture healing. CP-533536 demonstrates excellent in vitro potency against EP2 and selectivity against a broad panel of other targets. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 660.2±65.0 °C at 760 mmHg |
| Molecular Formula | C25H28N2O5S |
| Molecular Weight | 468.565 |
| Flash Point | 353.0±34.3 °C |
| Exact Mass | 468.171906 |
| PSA | 105.18000 |
| LogP | 4.78 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.600 |
| Storage condition | 2-8℃ |
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~%
223488-57-1 |
| Literature: US2005/65133 A1, ; Page/Page column 45 ; |
| Precursor 0 | |
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| DownStream 1 | |
![sodium,2-[3-[[(4-tert-butylphenyl)methyl-pyridin-3-ylsulfonylamino]methyl]phenoxy]acetate structure](https://image.chemsrc.com/caspic/226/223490-49-1.png)