1260177-41-0

1260177-41-0 structure

Name: 2-Chloro-9-[(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)]-9H-purine
Chemical Name: (2R,3R,4R,5R)-2-(acetoxymethyl)-5-(2-chloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate
CAS Number: 1260177-41-0
Molecular Formula: C₁₆H₁₇ClN₄O₇
Molecular Weight: 412.78
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2016-08-08 22:48:05
Modify Date: 2024-01-13 08:06:19
2-Chloro-9-[(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)]-9H-purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(2-chloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate

Description	2-Chloro-9-[(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)]-9H-purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

107037-21-8

~87%

1260177-41-0

Literature: Gillerman, Irina; Fischer, Bilha Journal of Medicinal Chemistry, 2011 , vol. 54, # 1 p. 107 - 121