24160-36-9

24160-36-9 structure

Name: Trametenolic acid
Chemical Name: (2R)-2-[(3S,5R,10S,13R,14R)-3-hydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methylhept-5-enoic acid
CAS Number: 24160-36-9
Molecular Formula: C₃₀H₄₈O₃
Molecular Weight: 456.70000
Catalog: Research Areas Inflammation/Immunology
Create Date: 2017-12-19 00:03:38
Modify Date: 2024-01-11 12:57:46
Trametenolic acid is a lanostanol glycoside that isolated from the EtOH extract of the fruit bodies of Laetiporus versisporus[1].

Name	(2R)-2-[(3S,5R,10S,13R,14R)-3-hydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methylhept-5-enoic acid
Synonyms	Trametenolic acid (+)-trametenolic acid B Lanosta-8,24-dien-21-oic acid,3-hydroxy-,(3beta) 3beta-Hydroxylanosta-8,24-dien-21-oic acid

Description	Trametenolic acid is a lanostanol glycoside that isolated from the EtOH extract of the fruit bodies of Laetiporus versisporus[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	ERK1 ERK2
In Vitro	Trametenolic acid (1 mg/mL; 15-30 mins) induces the upregulation of autophagy-related proteins (Beclin-1, Atg12, and LC3) in B16-F1 cells by activating the ERK1/2 signaling pathway[1]. Trametenolic acid (1 mg/mL; 24 hours; B16-F1 cells) has dual synergic mechanisms to exert an anti-melanogenetic effect[1]. Trametenolic acid (0.1-4 mg/mL; 52 hours; B16-F1 cells) increase melanin synthesis by approximately 20% and 40% in cells transfected with siRNAs against mTOR and Atg5, respectively[1]. Western Blot Analysis[1] Cell Line: B16-F1 cells Concentration: 1 mg/mL Incubation Time: 15 and 30 mins Result: Increased the expression levels of phospho-p38, phospho-ERK1/2, Beclin-1, Atg12 and LC3 by approximately 46%, 10%, 48%, 126% and 49%, respectively. Western Blot Analysis[1] Cell Line: B16-F1 cells Concentration: 1 mg/mL Incubation Time: 24 hours Result: Increased the expression of ERK1/2 and p-ERK1/2 and decreased MITF, tyrosinase, and TRP 1 levels.
References	[1]. K Yoshikawa, et al. New lanostanoid glycosides from the fruit body of laetiporus versisporus. J Nat Prod. 1999 Apr;62(4):543-5.