- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Mc-Val-Cit-PABC-PNP
- Price:
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Yang
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: Mc-Val-Cit-PABC-PNP（VCMMAE linker）
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Stocking Period: 1 Day
- Contact: Tony Lai
- DC Chemicals Limited
- China
- Product Name: Mc-Val-Cit-PABC-PNP（VCMMAE linker）
- Price: $400.0/100mg $700.0/250mg $1300.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Taiwan Oyi peptide Co. Ltd
- China
- Product Name: Mc-Val-Cit-PABC-PNP
- Price: $Inquiry/1mg $Inquiry/100kg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Vinnie
159857-81-5
159857-81-5 structure
- Name: Mc-Val-Cit-PABC-PNP
- Chemical Name: MC-Val-Cit-PABC-PNP
- CAS Number: 159857-81-5
- Molecular Formula: C35H43N7O11
- Molecular Weight: 737.756
- Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
- Create Date: 2017-02-26 16:03:18
- Modify Date: 2024-01-09 19:40:08
-
Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Name | MC-Val-Cit-PABC-PNP |
|---|---|
| Synonyms |
maleimidocaproyl-val-Cit-PAB-OCOpNP
N-[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N[4-({[(4-nitrophenoxy)carbonyl]oxy}methyl)phenyl]-L-ornithinamide L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]- 4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-ureidopentanamido)benzyl (4-nitrophenyl)carbonate N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N-carbamoyl-N-[4-({[(4-nitrophenoxy)carbonyl]oxy}methyl)phenyl]-L-ornithinamide N-[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N-[4-({[(4-nitrophenoxy)carbonyl]oxy}methyl)phenyl]-L-ornithinamide maleimido-caproyl-valine-citrulline-para-aminobenzyl-4-nitrophenylcarbonate MC-VAL-CIT-PAB-PNB Mc-Val-Cit-PABC-PNP |
| Description | Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
|---|---|
| Related Catalog | |
| References |
[1]. Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 1034.5±65.0 °C at 760 mmHg |
| Molecular Formula | C35H43N7O11 |
| Molecular Weight | 737.756 |
| Flash Point | 579.4±34.3 °C |
| Exact Mass | 737.302063 |
| PSA | 261.15000 |
| LogP | 2.71 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.599 |
| Storage condition | 2~8℃ |
|
~%
159857-81-5 |
| Literature: WO2007/8603 A1, ; Page/Page column 137; 166; 167 ; |
