Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Sulfamonomethoxine
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Sulfamonomethoxine
Price: ￥138.0/100mg ￥218.0/5g ￥658.0/25g
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: Sulfamonmethoxine
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Sulfamonmethoxine
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Purity: 98.9%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Sulfamonomethoxine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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1220-83-3

1220-83-3 structure

Name: Sulfamonomethoxine
Chemical Name: Sulfamonomethoxine
CAS Number: 1220-83-3
Molecular Formula: C₁₁H₁₂N₄O₃S
Molecular Weight: 280.303
Catalog: API Synthetic anti-infective drugs Sulfonamides and synergists
Create Date: 2018-02-06 08:00:00
Modify Date: 2024-01-02 12:09:03
Sulfamonomethoxine is a long acting sulfonamide antibacterial agent, used in blood kinetic studies,and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate.

Name	Sulfamonomethoxine
Synonyms	benzenesulfonamide, 4-amino-N-(6-methoxy-4-pyrimidinyl)- sulfamonomethoxine 4-amino-N-(6-methoxy-4-pyrimidinyl)benzenesulfonamide N-(6-Methoxy-4-pyrimidinyl)sulfanilamide 4-amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide MFCD00063466 Sulfamonomethoxin 4-Methoxy-6-sulfanilamidopyrimidine

Description	Sulfamonomethoxine is a long acting sulfonamide antibacterial agent, used in blood kinetic studies,and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection

Density	1.3936
Boiling Point	513℃
Melting Point	203-206°C
Molecular Formula	C₁₁H₁₂N₄O₃S
Molecular Weight	280.303
Flash Point	>110°
Exact Mass	280.063019
PSA	115.58000
LogP	-0.04
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.6200
Storage condition	Keep in dark place,Inert atmosphere,2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WP0550000

CHEMICAL NAME :: Sulfanilamide, N(sup 1)-(6-methoxy-4-pyrimidinyl)-

CAS REGISTRY NUMBER :: 1220-83-3

BEILSTEIN REFERENCE NO. :: 0621128

LAST UPDATED :: 199612

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C11-H12-N4-O3-S

MOLECULAR WEIGHT :: 280.33

WISWESSER LINE NOTATION :: T6N CNJ DO1 FMSWR DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - irritability Lungs, Thorax, or Respiration - acute pulmonary edema

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,133,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2440 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - irritability Lungs, Thorax, or Respiration - acute pulmonary edema

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,133,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >7 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - irritability Lungs, Thorax, or Respiration - acute pulmonary edema

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,133,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4680 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 58,59,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 865 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: STRAAA Strahlentherapie. (Urban & Schwarzenberg, Postfach 202440, D-8000 Munich 2, Fed. Rep. Ger.) V.1- 1912- Volume(issue)/page/year: 127,245,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >7 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - irritability Lungs, Thorax, or Respiration - acute pulmonary edema

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,133,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1010 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,391,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Lungs, Thorax, or Respiration - acute pulmonary edema

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,133,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - acute pulmonary edema

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,133,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - food intake (animal) Lungs, Thorax, or Respiration - acute pulmonary edema

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,133,1975 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3 gm/kg

SEX/DURATION :: female 9-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

REFERENCE :: SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 13,7,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3 gm/kg

SEX/DURATION :: female 7-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

REFERENCE :: SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 13,7,1973

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H317-H319-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	WP0550000
HS Code	2935009090

100-05-0

1220-83-3

Literature: Pharmaceutical Chemistry Journal, , vol. 14, # 9 p. 640 - 644 Khimiko-Farmatsevticheskii Zhurnal, , vol. 14, # 9 p. 87 - 91

1748-50-1

1220-83-3

Literature: Pharmaceutical Chemistry Journal, , vol. 14, # 9 p. 640 - 644 Khimiko-Farmatsevticheskii Zhurnal, , vol. 14, # 9 p. 87 - 91

98-74-8

1220-83-3

Literature: Pharmaceutical Chemistry Journal, , vol. 14, # 9 p. 640 - 644 Khimiko-Farmatsevticheskii Zhurnal, , vol. 14, # 9 p. 87 - 91

Precursor 3
100-05-0 1748-50-1 98-74-8
DownStream 0

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

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