201216-42-4

201216-42-4 structure

Name: 3-AQC
Chemical Name: 3-(4-allylpiperazin-1-yl)-2-quinoxalinecarbonitrile maleate
CAS Number: 201216-42-4
Molecular Formula: C₂₀H₂₁N₅O₄
Molecular Weight: 395.41200
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2016-10-24 10:50:32
Modify Date: 2024-01-11 16:12:42
3-AQC, a piperazinylquinoxaline derivative, is a potent and competitive 5-HT3 receptor antagonist[1].

Name	3-(4-allylpiperazin-1-yl)-2-quinoxalinecarbonitrile maleate
Synonyms	3-aqc

Description	3-AQC, a piperazinylquinoxaline derivative, is a potent and competitive 5-HT3 receptor antagonist[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT3 Receptor
In Vitro	3-AQC (化合物 7e) 的效力几乎比 Tropisetron (HY-B0072) 强 100 倍。在豚鼠回肠中对 2-methyl-5HT 的拮抗作用的 pA2 为10.2[1]。
References	[1]. A Monge, et al. Novel antagonists of 5-HT3 receptors. Synthesis and biological evaluation of piperazinylquinoxaline derivatives. J Med Chem. 1993 Sep 17;36(19):2745-50.