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54784-44-0

54784-44-0 structure
54784-44-0 structure
  • Name: a d lh-rh
  • Chemical Name: a d lh-rh
  • CAS Number: 54784-44-0
  • Molecular Formula: C59H79N15O13
  • Molecular Weight: 1206.35000
  • Catalog: Research Areas Endocrinology
  • Create Date: 2018-12-29 22:47:32
  • Modify Date: 2024-04-05 14:50:36
  • [D-Phe2,D-Ala6]-LH-RH is a potent LH-RH antagonist. [D-Phe2,D-Ala6]-LH-RH shows anti-LH/FSH-RH and antiovulatory activities[1].
Name a d lh-rh
Synonyms GLP-DPHE-TRP-SER-TYR-DALA-LEU-ARG-PRO-GLY-NH2
[D-PHE2,D-ALA6]-LH-RH (HUMAN)
PYR-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2
[D-PHE2,D-ALA6]-LH-RH
PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2
D-phe2,D-ala6-luteinizing hormone*releasing hormo
wy-18,185
LHRH,Phe(2)-Ala(6)
(d-phe(sup2))-(d-ala(sup6))-lhrh
Description [D-Phe2,D-Ala6]-LH-RH is a potent LH-RH antagonist. [D-Phe2,D-Ala6]-LH-RH shows anti-LH/FSH-RH and antiovulatory activities[1].
Related Catalog
In Vivo [D-Phe2,D-Ala6]-LH-RH inhibits the LH and FSH release induced by LH-RH in immature male rats[1]. [D-Phe2,D-Ala6]-LH-RH (1 mg/rat, SC) shows marked antiovulatory and contraceptive activity[2].[D-Phe2,D-Ala6]-LH-RH (0.625, 1.25, 2.5 mg/kg; s.c.; single dose; sacrificed 30 minutes) results a dose-dependent increase in stalk-median eminence (SME)-LHRH activity and decreases plasma LHRH activity as well in rats with hypophysectomized (hypox) at 25 days old[3]. [D-Phe2,D-Ala6]-LH-RH (25 mg/kg; s.c.; single dsoe) is effective in blocking the ovulation normally induced by LRH alone[4]. Animal Model: Adult female Sprague-Dawley rats (200-250 g)[2] Dosage: 1 mg/rat Administration: SC injections, from 12:00 to 14:30 hr on the day of proestrus Result: Showed marked antiovulatory and contraceptive activity, with 96% inhibition of ovulation.
References

[1]. Vilchez-Martinez JA, et al. Comparison of the anti-LH/FSH-RH and anti-ovulatory activities of (D-Phe2, D-Leu6)-LH-RH and (D-Phe2, D-Ala6)-LH-RH. Endocr Res Commun. 1976;3(3-4):231-41.

[2]. Beattie CW, et al. Luteinizing hormone-releasing hormone. Antiovulatory activity of analogs substituted in positions 2 and 6. J Med Chem. 1975 Dec;18(12):1247-50.

[3]. Corbin A, et al. Effect of luteinizing hormone releasing hormone (LHRH) and an LHRH antagonist of hypothalamic and plasma LHRH of hypophysectomized rats. Endocrinology. 1976 Jan;98(1):247-50.

[4]. Corbin A, et al. Ihibition of the pre-ovulatory proestrous gonadotropin surge, ovulation and pregnancy with a peptide analogue of luteinizing hormone releasing hormone. Endocr Res Commun. 1975;2(1):1-23.

Density 1.46g/cm3
Molecular Formula C59H79N15O13
Molecular Weight 1206.35000
Exact Mass 1205.60000
PSA 443.45000
LogP 2.77280
Index of Refraction 1.687

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OK6600000
CHEMICAL NAME :
Luteinizing hormone-releasing hormone, (D-phe(sup 2))-(D-ala(sup 6))-
CAS REGISTRY NUMBER :
54784-44-0
LAST UPDATED :
198910
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C59-H79-N15-O13
MOLECULAR WEIGHT :
1206.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
3750 ug/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,1247,1975
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
2500 ug/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969- Volume(issue)/page/year: 16,359,1979
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
30 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
EDRCAM Endocrine Research Communcations. (New York, NY) V.1-9, 1974-83. Volume(issue)/page/year: 2,1,1975
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
12500 ug/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
EDRCAM Endocrine Research Communcations. (New York, NY) V.1-9, 1974-83. Volume(issue)/page/year: 2,1,1975
Risk Phrases 60
Safety Phrases 53-22-36/37/39-45

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