147600-40-6

147600-40-6 structure

Name: Ac-Leu-Val-Lys-aldehyde
Chemical Name: Ac-Leu-Val-Lys-aldehyde
CAS Number: 147600-40-6
Molecular Formula: C₁₉H₃₆N₄O₄
Molecular Weight: 384.51
Catalog: Signaling Pathways Metabolic Enzyme/Protease Cathepsin
Create Date: 2016-07-17 11:03:57
Modify Date: 2024-01-05 13:04:14
Ac-Leu-Val-Lys-Aldehyde is a potent cathepsin B inhibitor with IC50s of 4 nM. Ac-Leu-Val-Lys-Aldehyde significantly reduces quinolinic acid (HY-100807)-induced striatal cell death and causes accumulation of LC3-II[1].

Name	Ac-Leu-Val-Lys-aldehyde
Synonyms	cathepsin b inhibitor ii N-Acetyl-L-leucyl-N-[(2S)-6-amino-1-oxo-2-hexanyl]-L-valinamide L-Valinamide, N-acetyl-L-leucyl-N-[(1S)-5-amino-1-formylpentyl]- ac-lvk-cho acetyl-L-leucyl-L-valyl-L-lysinal ac-leu-val-l-lysinal

Description	Ac-Leu-Val-Lys-Aldehyde is a potent cathepsin B inhibitor with IC50s of 4 nM. Ac-Leu-Val-Lys-Aldehyde significantly reduces quinolinic acid (HY-100807)-induced striatal cell death and causes accumulation of LC3-II[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin
Target	Cathepsin B:4 nM (IC50)
References	[1]. McConnell RM, et al. Inhibition studies of some serine and thiol proteinases by new leupeptin analogues. J Med Chem. 1993 Apr 16;36(8):1084-9. [2]. Wang YR, et al. Cathepsin L plays a role in quinolinic acid-induced NF-Κb activation and excitotoxicity in rat striatal neurons. PLoS One. 2013 Sep 20;8(9):e75702.