73-03-0

73-03-0 structure

Name: Cordycepin
Chemical Name: Cordycepin
CAS Number: 73-03-0
Molecular Formula: C₁₀H₁₃N₅O₃
Molecular Weight: 251.242
Catalog: Biochemical Nucleoside drugs Deoxynucleotides and their analogues
Create Date: 2018-03-02 08:00:00
Modify Date: 2024-01-02 18:58:22
Cordycepin, which is a nucleoside derivative isolated from Cordyceps, inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner.

Name	Cordycepin
Synonyms	9H-Purin-6-amine, 9-(3-deoxy-β-D-erythro-pentofuranosyl)- Adenine cordyceposide EINECS 200-791-4 9H-Purine, 6-amino-9-(3-deoxy-β-D-ribofuranosyl)- Adenosine,3-deoxy Cordycepine MFCD00037998 Cordycepin Cordyceps fungus powder cordycepin crystalline 3'-Deoxyadenosine adenosine, 3'-deoxy- (-)-cordycepin 3'-Deoxy-D-adenosine

Description	Cordycepin, which is a nucleoside derivative isolated from Cordyceps, inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Natural Products >> Alkaloid Research Areas >> Cancer Research Areas >> Inflammation/Immunology
Target	MMP-1 MMP-3
In Vitro	Cordycepin is a potent inhibitor of IL-1β-induced chemokine production and MMP expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs. The effect of Cordycepin on cellular toxicity of RASFs is assessed using MTT assay. Treatment of RASFs with Cordycepin (50 μM or 100 μM) for 24 h does not cause any significant change in cell viability. However, cell viability is slightly decreased when cells are incubated with 100 μM Cordycepin for 48 h[1].
Cell Assay	RASFs (2×104 cells/well) are treated with various concentrations of Cordycepin (50 μM or 100 μM). After incubation for 1 h, 12 h and 24 h, cells are washed twice with PBS, MTT (0.5 mg/mL PBS) is added to each well and incubated at 37°C for 30 min. Formazan crystals formed are dissolved by adding DMSO (100 μL/well) and the absorbance is read at 570 nm using a microplate reader[1].
References	[1]. Noh EM, et al. Cordycepin inhibits IL-1beta-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts. Rheumatology (Oxford). 2009 Jan;48(1):45-8.

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 35,119,1982

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H315-H319-H335
Precautionary Statements	P261-P301 + P310-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T:Toxic
Risk Phrases	R25;R36/37/38
Safety Phrases	S26-S45
RIDADR	UN 2811
WGK Germany	3
RTECS	AU7358610
HS Code	29349990

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%