80225-53-2
80225-53-2 structure
- Name: Rosmanol
- Chemical Name: Rosmanol
- CAS Number: 80225-53-2
- Molecular Formula: C20H26O5
- Molecular Weight: 346.41700
- Catalog: Biochemical Plant extracts
- Create Date: 2018-08-14 18:25:18
- Modify Date: 2024-01-03 19:15:15
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Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect.
| Name | Rosmanol |
|---|---|
| Synonyms |
Oxydesaminoisorosmaricin
(4bR,8aS,9S,10S)-3,4,10-Trihydroxy-2-isopropyl-8,8-dimethyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epoxymethano)phenanthren-12-one |
| Description | Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect. |
|---|---|
| Related Catalog | |
| In Vitro | Rosmanol exhibits the strongest inhibition on cell viability with IC50 approximately 42 μM. Rosmanol might suppress cancer cell proliferation or induce cancer cell undergoing apoptosis that lead to cell growth-inhibition. With 50 μM of Rosmanol treatment, the percentage of COLO 205 cells undergoing apoptosis increase dramatically from 9 h (29%) to 24 h (51%). Within 24 h of treatment with 50 μM Rosmanol, COLO 205 cells exhibit significant morphological changes and chromosomal condensation, which is indicative of apoptotic cell death[1]. Carnosol is a lipid protector against attack by O2[2]. |
| References |
| Density | 1.33 |
|---|---|
| Boiling Point | 574.186ºC at 760 mmHg |
| Molecular Formula | C20H26O5 |
| Molecular Weight | 346.41700 |
| Flash Point | 205.663ºC |
| Exact Mass | 346.17800 |
| PSA | 86.99000 |
| LogP | 3.25770 |
| Index of Refraction | 1.625 |
| Storage condition | 2-8℃ |
| HS Code | 2932999099 |
|---|
|
~73%
80225-53-2 |
| Literature: Marrero, Joaquin G.; Andres, Lucia S.; Luis, Javier G. Journal of Natural Products, 2002 , vol. 65, # 7 p. 986 - 989 |
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~%
80225-53-2 |
| Literature: Masuda, Toshiya; Inaba, Yuzuru; Maekawa, Tomomi; Takeda, Yoshio; Tamura, Hirotoshi; Yamaguchi, Hidemasa Journal of Agricultural and Food Chemistry, 2002 , vol. 50, # 21 p. 5863 - 5869 |
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~%
80225-53-2 |
| Literature: Masuda, Toshiya; Kirikihira, Takuya; Takeda, Yoshio Journal of Agricultural and Food Chemistry, 2005 , vol. 53, # 17 p. 6831 - 6834 |
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~%
80225-53-2 |
| Literature: Marrero, Joaquin G.; Andres, Lucia S.; Luis, Javier G. Journal of Natural Products, 2002 , vol. 65, # 7 p. 986 - 989 |
| Precursor 3 | |
|---|---|
| DownStream 0 | |
| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |