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91431-42-4

91431-42-4 structure
91431-42-4 structure
  • Name: Methotrexate
  • Chemical Name: (4-acetyloxy-6-chloro-2,3-dimethoxynaphthalen-1-yl) acetate
  • CAS Number: 91431-42-4
  • Molecular Formula: C16H15ClO6
  • Molecular Weight: 338.74000
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease 5-Lipoxygenase
  • Create Date: 2018-06-22 14:29:07
  • Modify Date: 2024-01-19 21:18:25
  • RS4317 is a topically effective 5-lipoxygenase (5-LO) inhibitor.

Name (4-acetyloxy-6-chloro-2,3-dimethoxynaphthalen-1-yl) acetate
Synonyms 6-chloro-1,4-diacetoxy-2,3-dimethoxynaphthalene
LONAPALENE
Lonapaleno
Lonapalenum
6-chloro-2,3-dimethoxy-1,4-naphthalenediol
1,4-diacetoxy-6-chloro-2,3-dimethoxynaphthalene
6-chloro-1,4-diacetyloxy-2,3-dimethoxynaphthalene
Methotrexate
RS4317
Description RS4317 is a topically effective 5-lipoxygenase (5-LO) inhibitor.
Related Catalog
Target

5-lipoxygenase[1]

In Vitro RS4317 (Lonapalene) may be useful in the treatment of psoriasis, and that leukotriene B4 is a relevant mediator of the pathology of this disease[1].
References

[1]. Black AK, et al. Pharmacologic and clinical effects of lonapalene (RS 43179), a 5-lipoxygenase inhibitor, in psoriasis. J Invest Dermatol. 1990 Jul;95(1):50-4.

Density 1.309g/cm3
Boiling Point 424.9ºC at 760mmHg
Molecular Formula C16H15ClO6
Molecular Weight 338.74000
Flash Point 159.3ºC
Exact Mass 338.05600
PSA 71.06000
LogP 3.36100
Index of Refraction 1.571