90697-57-7

90697-57-7 structure

Name: Motapizone
Chemical Name: 3-(4-imidazol-1-ylthiophen-2-yl)-4-methyl-4,5-dihydro-1H-pyridazin-6-one
CAS Number: 90697-57-7
Molecular Formula: C₁₂H₁₂N₄OS
Molecular Weight: 260.31
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2018-07-13 15:51:14
Modify Date: 2024-01-06 15:35:10
Motapizone (NAT 05-239) is a selective PDE3 inhibitor. Motapizone moderately inhibits cytokine release in lipopolysaccharide (LPS)-induced alveolar macrophages. Motapizone also inhibits human platelet aggregation by increasing intracellular cAMP[1][2].

Name	3-(4-imidazol-1-ylthiophen-2-yl)-4-methyl-4,5-dihydro-1H-pyridazin-6-one
Synonyms	Motapizone UNII-C4A61P8A37 Motapizonum Motapizona Motapizon

Description	Motapizone (NAT 05-239) is a selective PDE3 inhibitor. Motapizone moderately inhibits cytokine release in lipopolysaccharide (LPS)-induced alveolar macrophages. Motapizone also inhibits human platelet aggregation by increasing intracellular cAMP[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology
Target	PDE3
In Vitro	Motapizone (10 μM; 加氧化剂前 15 min) 在氧化应激条件下，对脂多糖 (LPS) 诱导的肺泡巨噬细胞的细胞因子释放有 20% 的抑制率，不过，这种抑制作用不受氧化应激影响[1]。
References	[1]. Milara J, et al. Oxidative stress-induced glucocorticoid resistance is prevented by dual PDE3/PDE4 inhibition in human alveolar macrophages. Clin Exp Allergy. 2011 Apr;41(4):535-46. [2]. Borbe HO, et al. Inhibition of human platelet aggregation by motapizone via an increase in intracellular cAMP. Agents Actions Suppl. 1986;20:249-57.