205432-12-8

205432-12-8 structure

Name: JS-K
Chemical Name: (Z)-(2,4-dinitrophenoxy)imino-(4-ethoxycarbonylpiperazin-1-yl)-oxidoazanium
CAS Number: 205432-12-8
Molecular Formula: C₁₃H₁₆N₆O₈
Molecular Weight: 384.30200
Create Date: 2017-07-31 12:12:32
Modify Date: 2024-01-06 13:09:41
JS-K is a NO donor that reacts with glutathione to generate NO at physiological pH[1]. JS-K inhibits proliferation, induces apoptosis, and disrupts the cell cycle of Jurkat T acute lymphoblastic leukemia cells[2].

Name	(Z)-(2,4-dinitrophenoxy)imino-(4-ethoxycarbonylpiperazin-1-yl)-oxidoazanium
Synonyms	HMS3261L12 O2-(2,4-Dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate JS-K

Description	JS-K is a NO donor that reacts with glutathione to generate NO at physiological pH[1]. JS-K inhibits proliferation, induces apoptosis, and disrupts the cell cycle of Jurkat T acute lymphoblastic leukemia cells[2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> NO Synthase
References	[1]. Shami PJ, et al. JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity. Mol Cancer Ther. 2003 Apr;2(4):409-17.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TL1364200

Precursor 0
DownStream 1
120-43-4