28610-31-3

28610-31-3 structure

Name: 8-prenylkaempferol
Chemical Name: 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one
CAS Number: 28610-31-3
Molecular Formula: C₂₀H₁₈O₆
Molecular Weight: 354.353
Catalog: Natural product Flavonoids
Create Date: 2016-04-25 22:08:29
Modify Date: 2024-01-06 10:38:32
Desmethylicaritin is a phytoestrogenic molecule, has inducible effect on directional differentiation of embryonic stem cells into cardiomyocytes. Desmethylicaritin also suppresses adipogenesis via Wnt/β-catenin signaling pathway[1][2].

Name	3,5,7-trihydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one
Synonyms	3,5,7-trihydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one Noranhydroicaritin 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-chromen-4-one 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)- 4'-Desmethylicaritin Desmethyl Icaritin De-O-methylanhydroicaritin 8-Prenylkaempferol desmethylanhydroicaritin

Description	Desmethylicaritin is a phytoestrogenic molecule, has inducible effect on directional differentiation of embryonic stem cells into cardiomyocytes. Desmethylicaritin also suppresses adipogenesis via Wnt/β-catenin signaling pathway[1][2].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Wnt Research Areas >> Metabolic Disease
In Vitro	去甲基菌素是血清中淫羊藿类黄酮的生物活性代谢产物[1]。去甲基甘草素 (0.1, 1, 10 μM; 48 h) 以剂量依赖的方式抑制 3T3-L1 细胞的脂肪生成并抑制脂肪生成过程中的克隆扩增[1]。去甲基孢菌素 (10 μM; 48 h) 不影响 CCAAT/增强子结合蛋白 δ 和 β 的 mRNA 的表达，但降低了 CCAAT/增强子结合蛋白 α、过氧化物酶体增殖物激活受体 γ、脂肪细胞脂质结合蛋白和脂蛋白脂肪酶的mRNA表达[1]。去甲基孢菌素 (10 μM; 2、4、6、10 d) 增加了细胞质和细胞核中 β-catenin 的蛋白表达，免疫荧光结果证实去甲基化菌素增加了 β-catenin 的核转运[1]。
References	[1]. Wang XL, et al. Phytoestrogenic molecule desmethylicaritin suppressed adipogenesis via Wnt/β-catenin signaling pathway. Eur J Pharmacol. 2013 Aug 15;714(1-3):254-60. [2]. Zhu DY, et al. Inducible effects of icariin, icaritin, and desmethylicaritin on directional differentiation of embryonic stem cells into cardiomyocytes in vitro. Acta Pharmacol Sin. 2005 Apr;26(4):477-85.

Hazard Codes	Xi
HS Code	2914501900

118525-40-9

28610-31-3

Literature: Zhang, Nan; Calderwood, Stuart K. Patent: US2008/214844 A1, 2008 ; Location in patent: Page/Page column 2 ;

143724-76-9

~82%

28610-31-3

Literature: Fukai, Toshio; Nomura, Taro Heterocycles, 1992 , vol. 34, # 6 p. 1213 - 1225

852247-44-0

~73%

28610-31-3

520-18-3

780724-90-5

28610-31-3

Literature: Yamamoto, Hirobumi; Senda, Masayuki; Inoue, Kenichiro Phytochemistry, 2000 , vol. 54, # 7 p. 649 - 655

143724-66-7

28610-31-3

Literature: Fukai, Toshio; Nomura, Taro Heterocycles, 1992 , vol. 34, # 6 p. 1213 - 1225

520-18-3

28610-31-3

Literature: Fukai, Toshio; Nomura, Taro Heterocycles, 1992 , vol. 34, # 6 p. 1213 - 1225

143724-70-3

28610-31-3

870-63-3

28610-31-3

Literature: Fukai, Toshio; Nomura, Taro Heterocycles, 1992 , vol. 34, # 6 p. 1213 - 1225

HS Code	2914501900
Summary	2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%