16589-24-5

16589-24-5 structure

Name: Sympatol {Tartrate}
Chemical Name: Synephrine Tartrate
CAS Number: 16589-24-5
Molecular Formula: C₂₂H₃₂N₂O₁₀
Molecular Weight: 317.292
Catalog: Biochemical Natural product
Create Date: 2018-07-12 19:27:52
Modify Date: 2024-01-05 11:38:32
Synephrine (Oxedrine) hemitartrate, an alkaloid, is an α-adrenergic and β-adrenergic agonist derived from the Citrus aurantium. Synephrine hemitartrate is a sympathomimetic compound and can be used for weight loss[1][2].

Name	Synephrine Tartrate
Synonyms	Corvasymton {Tartrate} Sympathol {Tartrate} DL-4-HYDROXY-ALPHA-(METHYLAMINOMETHYL)BENZYL ALCOHOL D-TARTRATE EINECS 240-647-8 (±)-1-(4-Hydroxyphenyl)-2-methylaminoethanol tartrate 4-[1-hydroxy-2-(methylamino)ethyl]phenol 2,3-dihydroxybutanedioate (1:1) 1-(4-Hydroxyphenyl)-2-(methylamino)ethanol tartrate 2,3-dihydroxybutanedioic acid,4-[1-hydroxy-2-(methylamino)ethyl]phenol Simpadren {Tartrate} Sympatol {Tartrate} Synephrine tartrate 4-[1-Hydroxy-2-(methylamino)ethyl]phenol 2,3-dihydroxysuccinate (1:1) MFCD00151120 Benzenemethanol, 4-hydroxy-α-[(methylamino)methyl]-, 2,3-dihydroxybutanedioate (1:1) (salt)

Description	Synephrine (Oxedrine) hemitartrate, an alkaloid, is an α-adrenergic and β-adrenergic agonist derived from the Citrus aurantium. Synephrine hemitartrate is a sympathomimetic compound and can be used for weight loss[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
In Vivo	Synephrine (1 mg/kg; oral gavage; for 8 days; PVL and BDL rats) significantly ameliorates the hyperdynamic state in both PVL and BDL rats. The portal venous pressure in PVL and BDL rats, portal tributary blood flow and cardiac index are significantly reduced, while mean arterial pressure and systemic as well as portal territory vascular resistance are enhanced by treatment of Synephrine[2]. Animal Model: Portal vein ligation (PVL) or bile duct ligation (BDL) rats[2]. Dosage: 1 mg/kg per 12 hours Administration: Oral gavage; for 8 days Result: The portal venous pressure in PVL and BDL rats, portal tributary blood flow and cardiac index were significantly reduced, while mean arterial pressure and systemic as well as portal territory vascular resistance were enhanced.
References	[1]. Thomas JE, et al. STEMI in a 24-year-old man after use of a synephrine-containing dietary supplement: a case report and review of the literature. Tex Heart Inst J. 2009;36(6):586-90. [2]. Huang YT, et al. Hemodynamic effects of synephrine treatment in portal hypertensive rats. Jpn J Pharmacol. 2001 Feb;85(2):183-8.

Risk Phrases	R36/37/38
Safety Phrases	S26-S36/37/39