Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin
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Purity: 98.0%
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599150-20-6

599150-20-6 structure

Name: HPI-1
Chemical Name: 2-methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate
CAS Number: 599150-20-6
Molecular Formula: C₂₇H₂₉NO₆
Molecular Weight: 463.522
Catalog: Signaling Pathways Stem Cell/Wnt Gli
Create Date: 2016-01-19 00:09:23
Modify Date: 2024-01-05 21:51:31
GLI antagonist-1 is a potent GLI antagonist with an IC50 value of 1.1 µM. GLI antagonist-1 shows anti-proliferative activity. GLI antagonist-1 decreases the GLI1 mRNA expression. GLI antagonist-1 inhibits colony formation in a dose-dependent manner[1].

Name	2-methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate
Synonyms	2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxylate 3-Quinolinecarboxylic acid, 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-, 2-methoxyethyl ester 2-methoxyethyl 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylate

Description	GLI antagonist-1 is a potent GLI antagonist with an IC50 value of 1.1 µM. GLI antagonist-1 shows anti-proliferative activity. GLI antagonist-1 decreases the GLI1 mRNA expression. GLI antagonist-1 inhibits colony formation in a dose-dependent manner[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Gli Research Areas >> Cancer
Target	IC50: 1.1 µM (GLI)[1]
In Vitro	GLI antagonist-1 (compound HPI-1) (0-25 µM; 72 h) shows anti-proliferative activity with IC50 values of 29, >25, 20.5 µM for SUM149, MDA-MB-231, SUM159 cells, respectively[1]. GLI antagonist-1 (10 µM; 72 h) decreases the GLI1 mRNA expression in SUM149 cells[1]. GLI antagonist-1 (5, 10, 20 µM) inhibits colony formation in a dose-dependent manner in SUM149 and MDA-MB-231 cells[1]. Cell Proliferation Assay[1] Cell Line: SUM149, MDA-MB-231, SUM159 cells Concentration: 0-25 µM Incubation Time: 72 h Result: Showed anti-proliferative activity with IC50 values of 29, >25, 20.5 µM for SUM149, MDA-MB-231, SUM159 cells, respectively.
References	[1]. Oladapo HO, et al. Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells. Cancer Lett. 2017 Dec 28;411:136-149.

HS Code	2933499090

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%