226907-52-4

226907-52-4 structure

Name: 6-amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol
Chemical Name: 6-amino-9-benzyl-2-(2-methoxyethoxy)-7H-purin-8-one
CAS Number: 226907-52-4
Molecular Formula: C₁₅H₁₇N₅O₃
Molecular Weight: 315.327
Create Date: 2016-06-21 06:48:36
Modify Date: 2024-01-22 10:52:36
SM-360320 (CL-087) is a potent, oral actively TLR7 agonist. SM-360320 is a mmuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response[1]. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity[2].

Name	6-amino-9-benzyl-2-(2-methoxyethoxy)-7H-purin-8-one
Synonyms	9-Benzyl-8-hydroxy-2-(2-methoxyethoxy)adenine Toll-Like Receptor 7 Ligand II TLR7 Ligand II 6-Amino-9-benzyl-2-(2-methoxyethoxy)-7,9-dihydro-8H-purin-8-one 6-Amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol 8H-Purin-8-one, 6-amino-7,9-dihydro-2-(2-methoxyethoxy)-9-(phenylmethyl)-

Description	SM-360320 (CL-087) is a potent, oral actively TLR7 agonist. SM-360320 is a mmuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response[1]. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity[2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Inflammation/Immunology
References	[1]. Dharmapuri S, et al. An oral TLR7 agonist is a potent adjuvant of DNA vaccination in transgenic mouse tumor models. Cancer Gene Ther. 2009;16(5):462-472. [2]. Lee J, et al. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006;103(6):1828-1833.

HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%