Shanghai Nianxing Industrial Co., Ltd
China
Product Name: carene
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Purity: 90.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: carene
Price: ￥198.0/25ml
Purity: 98.0%
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: 3-Carene, stabilized, 90%
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
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13466-78-9

13466-78-9 structure

Name: carene
Chemical Name: car-3-ene
CAS Number: 13466-78-9
Molecular Formula: C₁₀H₁₆
Molecular Weight: 136.234
Catalog: Flavors and spices Synthetic spice Hydrocarbon spice Olefin
Create Date: 2018-08-06 18:42:22
Modify Date: 2024-01-02 20:09:14
3-Carene is a bicyclic monoterpene in essential oils extracted from pine trees. 3-Carene inhibits nociceptive stimulus-induced inflammatory infiltrates and COX-2 overexpression, and with antinociceptive effect. 3-Carene stimulates the activity and expression of alkaline phosphatase that is an early phase marker of osteoblastic differentiation[1][2].

Name	car-3-ene
Synonyms	(±)-D3-Carene Bicyclo[4.1.0]hept-3-ene, 3,7,7-trimethyl- 3-Carene,stabilized 4,7,7-Trimethyl-3-norcarene MFCD00001315 3-δ-Carene 3,7,7-trimethyl-bicyclo[4.1.0]hept-3-ene 3,7,7-Trimethylbicyclo[4.1.0]hept-3-ene d3-carene (±)-3-Carene 3-carene EINECS 236-719-3 carene δ3-Carene Isodiprene

Description	3-Carene is a bicyclic monoterpene in essential oils extracted from pine trees. 3-Carene inhibits nociceptive stimulus-induced inflammatory infiltrates and COX-2 overexpression, and with antinociceptive effect. 3-Carene stimulates the activity and expression of alkaline phosphatase that is an early phase marker of osteoblastic differentiation[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Huang XL, e tal. Anti-inflammatory and antinociceptive effects of active ingredients in the essential oils from Gynura procumbens, a traditional medicine and a new and popular food material.J Ethnopharmacol. 2019 Jul 15;239:111916. [2]. Jeong JG, et al. Low concentration of 3-carene stimulates the differentiation of mouse osteoblastic MC3T3-E1 subclone 4 cells. Phytother Res. 2008 Jan;22(1):18-22.

Density	0.9±0.1 g/cm3
Boiling Point	171.4±0.0 °C at 760 mmHg
Melting Point	25°C
Molecular Formula	C₁₀H₁₆
Molecular Weight	136.234
Flash Point	46.1±0.0 °C
Exact Mass	136.125198
LogP	4.37
Appearance	Liquid \| Clear colorless to slightly yellow
Vapour Pressure	1.9±0.1 mmHg at 25°C
Index of Refraction	1.479
Stability	Stable. Flammable. Incompatible with strong oxidizing agents.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FH8400000

CHEMICAL NAME :: 3-Carene

CAS REGISTRY NUMBER :: 13466-78-9

BEILSTEIN REFERENCE NO. :: 1902766

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H16

MOLECULAR WEIGHT :: 136.26

WISWESSER LINE NOTATION :: L36 EUTJ B1 B1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 11,1053,1973 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 11,1053,1973

Symbol	GHS02, GHS07, GHS08
Signal Word	Danger
Hazard Statements	H226-H304-H315-H317
Precautionary Statements	P280-P301 + P310-P331-P333 + P313-P370 + P378-P403 + P235
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi
Risk Phrases	R10;R38;R43;R52/53
Safety Phrases	16-26-36/37-60-61-62-37-24
RIDADR	UN 2319 3/PG 3
WGK Germany	2
RTECS	FH8400000
Packaging Group	III
Hazard Class	3.2
HS Code	2902199090

3479-89-8

2158-55-6

7348-54-1

4755-36-6

Detail

Literature: Chemistry of Natural Compounds, , vol. 19, # 4 p. 422 - 425 Khimiya Prirodnykh Soedinenii, , vol. 19, # 4 p. 450 - 453

3479-89-8

~1%

2158-55-6

554-61-0

7348-54-1

Detail

Literature: Chemistry of Natural Compounds, , vol. 19, # 4 p. 422 - 425 Khimiya Prirodnykh Soedinenii, , vol. 19, # 4 p. 450 - 453

554-61-0

~10%

99-86-5

99-87-6

586-63-0

Detail

Literature: Journal of Physical Organic Chemistry, , vol. 16, # 1 p. 16 - 20

917-54-4

94806-25-4

78-79-5

13466-78-9

Literature: Journal of Organic Chemistry, , vol. 52, # 8 p. 1493 - 1500

15103-32-9

~4%

554-61-0

100102-73-6

103200-82-4

Detail

Literature: Journal of Organic Chemistry USSR (English Translation), , vol. 21, p. 1912 - 1914 Zhurnal Organicheskoi Khimii, , vol. 21, # 10 p. 2089 - 2091

936-91-4

~6%

2517-19-3

3479-89-8

86361-47-9

Detail

Literature: Journal of Organic Chemistry USSR (English Translation), , vol. 24, p. 106 - 110 Zhurnal Organicheskoi Khimii, , vol. 24, # 1 p. 121 - 126

Precursor 7
3479-89-8 554-61-0 917-54-4 94806-25-4
78-79-5 15103-32-9 936-91-4
DownStream 9
81800-50-2 107493-44-7 2225-98-1 1197-01-9
98-55-5 5208-37-7 67670-71-7 595-46-0
597-43-3

HS Code	2902199090
Summary	2902199090 other cyclanes, cyclenes and cyclotherpenes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

13466-78-9	29050-33-7
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