13849-91-7

13849-91-7 structure

Name: Pomolic acid
Chemical Name: pomolic acid
CAS Number: 13849-91-7
Molecular Formula: C₃₀H₄₈O₄
Molecular Weight: 472.700
Catalog: Natural product Moss
Create Date: 2018-06-15 15:55:53
Modify Date: 2024-01-02 13:06:29
Randialic acid A (Pomolic acid) is a pentacyclic triterpene isolated from Euscaphis japonica (Tunb.). Randialic acid A (Pomolic acid) inhibits tumor cells growth and induces cell apoptosis. Randialic acid A (Pomolic acid) has a potential for the treatment of prostate cancer (PC)[2].

Name	pomolic acid
Synonyms	Benthamic acid 3β,19-Dihydroxy-5α-urs-12-en-28-oic acid Urs-12-en-28-oic acid, 3,19-dihydroxy-, (3β)- (3β)-3,19-Dihydroxyurs-12-en-28-oic acid Randialic acid A 3β,19α-Dihydroxyurs-12-ene-28-oic acid 3β,19-Dihydroxyurs-12-en-28-oic acid (1R,2R,4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-1,10-dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid Serazide

Description	Randialic acid A (Pomolic acid) is a pentacyclic triterpene isolated from Euscaphis japonica (Tunb.). Randialic acid A (Pomolic acid) inhibits tumor cells growth and induces cell apoptosis. Randialic acid A (Pomolic acid) has a potential for the treatment of prostate cancer (PC)[2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
Target	IC50: apoptosis[1]
In Vitro	Randialic acid A (Pomolic acid) induces apoptosis of GBM cells as demonstrated by DNA fragmentation. Pomolic acid-induced apoptosis is dependent on reactive oxygen species (ROS) production. It also induces uncoupling of mitochondria membrane potential and activation of caspase-3 and -9[2].
References	[1]. Guimarães LPTP, et al. Pomolic acid induces apoptosis and inhibits multidrug resistance protein MRP1 and migration in glioblastoma cells.Oncol Rep. 2017 Oct;38(4):2525-2534. [2]. Park JH, et al.Pomolic Acid Ameliorates Fibroblast Activation and Renal Interstitial Fibrosis through Inhibition of SMAD-STAT Signaling Pathways.Molecules. 2018 Sep 3;23(9). pii: E2236.

Hazard Codes	Xi