Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Ethylenediaminetetraacetic-d<SUB>12</SUB> acid
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Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

203806-08-0

203806-08-0 structure

Name: EDTA-d12
Chemical Name: 2-[[2-[bis[carboxy(dideuterio)methyl]amino]-1,1,2,2-tetradeuterioethyl]-[carboxy(dideuterio)methyl]amino]-2,2-dideuterioacetic acid
CAS Number: 203806-08-0
Molecular Formula: C₁₀H₄D₁₂N₂O₈
Molecular Weight: 304.317
Catalog: Signaling Pathways Others Others
Create Date: 2018-03-08 08:00:00
Modify Date: 2024-01-02 18:57:41
EDTA-d12 is the deuterium labeled Ethylenediaminetetraacetic acid[1]. Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds[2][3][4].

Name	2-[[2-[bis[carboxy(dideuterio)methyl]amino]-1,1,2,2-tetradeuterioethyl]-[carboxy(dideuterio)methyl]amino]-2,2-dideuterioacetic acid
Synonyms	2,2',2'',2'''-[(H)Ethane-1,2-diyldinitrilo]tetra(H)acetic acid 2,2',2'',2'''-[(H)-1,2-Ethanediyldinitrilo]tetra(H)acetic acid Ethylenediaminetetraacetic-d12 acid MFCD00144285 EDTA-d12

Description	EDTA-d12 is the deuterium labeled Ethylenediaminetetraacetic acid[1]. Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds[2][3][4].
Related Catalog	Signaling Pathways >> Others >> Others
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Chumanov RS, et al. Artifact-inducing enrichment of ethylenediaminetetraacetic acid and ethyleneglycoltetraacetic acid on anion exchange resins. Anal Biochem. 2011 May 1;412(1):34-9. [3]. Banfi G, et al. The role of ethylenediamine tetraacetic acid (EDTA) as in vitro anticoagulant for diagnostic purposes. Clin Chem Lab Med. 200745(5):565-76. [4]. Ibad A, et al. Chelation therapy in the treatment of cardiovascular diseases. J Clin Lipidol. 2016 Jan-Feb10(1):58-62.

Density	1.6±0.1 g/cm3
Boiling Point	614.2±55.0 °C at 760 mmHg
Melting Point	250ºC (dec.)(lit.)
Molecular Formula	C₁₀H₄D₁₂N₂O₈
Molecular Weight	304.317
Flash Point	325.2±31.5 °C
Exact Mass	304.165985
PSA	155.68000
LogP	-0.43
Vapour Pressure	0.0±3.8 mmHg at 25°C
Index of Refraction	1.580

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319
Precautionary Statements	P305 + P351 + P338
Hazard Codes	Xi
RIDADR	UN 3077 9 / PGIII

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