936500-94-6

936500-94-6 structure

Name: Elinogrel
Chemical Name: 1-(5-chlorothiophen-2-yl)sulfonyl-3-[4-[6-fluoro-7-(methylamino)-2,4-dioxo-1H-quinazolin-3-yl]phenyl]urea
CAS Number: 936500-94-6
Molecular Formula: C₂₀H₁₅ClFN₅O₅S₂
Molecular Weight: 523.945
Catalog: Signaling Pathways GPCR/G Protein P2Y Receptor
Create Date: 2018-10-13 11:02:19
Modify Date: 2024-04-05 00:01:45
Elinogrel (PRT060128) is a potent, direct acting, competitive, and reversible platelet P2Y12 antagonist (IC50=20 nM). It is orally and intravenously available and has potent antiplatelet effects[1].

Name	1-(5-chlorothiophen-2-yl)sulfonyl-3-[4-[6-fluoro-7-(methylamino)-2,4-dioxo-1H-quinazolin-3-yl]phenyl]urea
Synonyms	2-Thiophenesulfonamide, 5-chloro-N-[[[4-[6-fluoro-1,4-dihydro-7-(methylamino)-2,4-dioxo-3(2H)-quinazolinyl]phenyl]amino]carbonyl]- 5-Chloro-N-({4-[6-fluoro-7-(methylamino)-2,4-dioxo-1,4-dihydro-3(2H)-quinazolinyl]phenyl}carbamoyl)-2-thiophenesulfonamide Elinogrel UNII-915Y8E749J

Description	Elinogrel (PRT060128) is a potent, direct acting, competitive, and reversible platelet P2Y12 antagonist (IC50=20 nM). It is orally and intravenously available and has potent antiplatelet effects[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> P2Y Receptor
Target	IC50: 20 nM (P2Y12)[2]
References	[1]. Angiolillo DJ, et al. Pharmacokinetic and pharmacodynamic effects of elinogrel: results of the platelet function substudyfrom the intravenous and oral administration of elinogrel to evaluate tolerability and efficacy in nonurgent percutaneous coronary intervention patients (INNOVATE-PCI) trial. Circ Cardiovasc Interv. 2012 Jun;5(3):347-56. [2]. Jacobson KA, et al. Pharmacochemistry of the platelet purinergic receptors. Purinergic Signal. 2011 Sep;7(3):305-24.