949588-40-3

949588-40-3 structure

Name: Org 25935
Chemical Name: N-{[(1R,2S)-6-Methoxy-1-phenyl-1,2,3,4-tetrahydro-2-naphthalenyl] methyl}-N-methylglycine hydrochloride (1:1)
CAS Number: 949588-40-3
Molecular Formula: C₂₁H₂₆ClNO₃
Molecular Weight: 375.89
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GlyT
Create Date: 2016-10-15 22:26:33
Modify Date: 2024-01-12 14:07:08
Org 25935 is a potent and selective glycine transporter 1 protein (GlyT1) inhibitor with an IC50 value of 100 nM. Org 25935 can decrease ethanol (EtOH) intake and EtOH preference in rats, whereas water intake is unaffected. Org 25935 can be used for researching alcohol dependence or abuse[1].

Name	N-{[(1R,2S)-6-Methoxy-1-phenyl-1,2,3,4-tetrahydro-2-naphthalenyl] methyl}-N-methylglycine hydrochloride (1:1)
Synonyms	Org 25935

Description	Org 25935 is a potent and selective glycine transporter 1 protein (GlyT1) inhibitor with an IC50 value of 100 nM. Org 25935 can decrease ethanol (EtOH) intake and EtOH preference in rats, whereas water intake is unaffected. Org 25935 can be used for researching alcohol dependence or abuse[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> GlyT Signaling Pathways >> Neuronal Signaling >> GlyT
Target	GlyT1:100 nM (IC50)
References	[1]. Molander A, et al. The glycine reuptake inhibitor Org 25935 decreases ethanol intake and preference in male wistar rats. Alcohol Alcohol. 2007;42(1):11-18.