133538-58-6

133538-58-6 structure

Name: I-SAP
Chemical Name: (E)-7-[3-[(4-iodophenyl)sulfonylamino]-6,6-dimethyl-4-bicyclo[3.1.1]heptanyl]hept-5-enoic acid
CAS Number: 133538-58-6
Molecular Formula: C₂₂H₃₀INO₄S
Molecular Weight: 531.447
Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
Create Date: 2016-03-29 21:09:11
Modify Date: 2024-07-04 17:46:03
I-SAP is a radioiodinated TXA2/PGH2 receptor antagonist. The bind between I-SAP and the receptors, is inhibited by the histidine modifying reagent diethyl-pyrocarbonate (DEPC)[1][2].

Name	(E)-7-[3-[(4-iodophenyl)sulfonylamino]-6,6-dimethyl-4-bicyclo[3.1.1]heptanyl]hept-5-enoic acid
Synonyms	5-Heptenoic acid, 7-[(1S,2S,3S,5R)-3-[[(4-iodophenyl)sulfonyl]amino]-6,6-dimethylbicyclo[3.1.1]hept-2-yl]-, (5Z)- Isap acid I-SAP (5Z)-7-[(1S,2S,3S,5R)-3-{[(4-Iodophenyl)sulfonyl]amino}-6,6-dimethylbicyclo[3.1.1]hept-2-yl]-5-heptenoic acid

Description	I-SAP is a radioiodinated TXA2/PGH2 receptor antagonist. The bind between I-SAP and the receptors, is inhibited by the histidine modifying reagent diethyl-pyrocarbonate (DEPC)[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor
Target	TXA2 Receptor
References	[1]. Saussy DL Jr, et al. Binding of a novel radioiodinated thromboxane A2/prostaglandin H2 antagonist to guinea pig lung membranes. Eicosanoids. 1992;5(1):1-4. [2]. Schrör K, et al. Inhibition of ligand binding to thromboxane A2/prostaglandin H2 receptors by diethylpyrocarbonate. Protection by receptor ligands and reversal by hydroxylamine. Biochem Pharmacol. 1995 Mar 30;49(7):921-7.