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32476-67-8

32476-67-8 structure
32476-67-8 structure
  • Name: Periplocymarin
  • Chemical Name: 4-[(3S,5S,10R,13R,14S,17S)-5,14-dihydroxy-3-[(2S,5R)-5-hydroxy-4-methoxy-6-methyl-oxan-2-yl]oxy-10,13-dimethyl-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-5H-furan-2-one
  • CAS Number: 32476-67-8
  • Molecular Formula: C30H46O8
  • Molecular Weight: 534.68100
  • Catalog: Research Areas Cancer
  • Create Date: 2017-08-26 07:25:45
  • Modify Date: 2024-01-09 18:30:09
  • Periplocymarin, a cardiac glycoside isolated from Periploca sepium and Periploca graeca, is a potential anti-cancer compound[1][2].
Name 4-[(3S,5S,10R,13R,14S,17S)-5,14-dihydroxy-3-[(2S,5R)-5-hydroxy-4-methoxy-6-methyl-oxan-2-yl]oxy-10,13-dimethyl-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-5H-furan-2-one
Synonyms periplocymarin
Description Periplocymarin, a cardiac glycoside isolated from Periploca sepium and Periploca graeca, is a potential anti-cancer compound[1][2].
Related Catalog
In Vitro Periplocymarin inhibits proliferation of PC3, U937, HCT-8, Bel-7402, BGC823, A549, and A2780 cell lines in vitro with IC50 values of 0.02-0.29 µM[2].
References

[1]. Martey ON, et al. Periplocymarin is a potential natural compound for drug development: highly permeable with absence of P-glycoprotein efflux and cytochrome P450 inhibitions. Biopharm Drug Dispos. 2014 May;35(4):195-206.

[2]. Redox-responsive PEGylated self-assembled prodrug-nanoparticles formed by single disulfidebond bridge periplocymarin-vitamin E conjugate for liver cancer chemotherapy. Drug Deliv. 2017 Nov;24(1):1170-1178.
Density 1.27±0.1 g/cm3 (20 ºC 760 Torr)
Boiling Point 690.9±55.0℃ at 760 mmHg
Melting Point 209-211 ºC
Molecular Formula C30H46O8
Molecular Weight 534.68100
Exact Mass 534.31900
PSA 114.68000
LogP 3.25430
Water Solubility Very slightly soluble (0.43 g/L) (25 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FH4920610
CHEMICAL NAME :
5-beta-Card-20(22)-enolide, 3-beta-((2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyran osyl)oxy)- 5,14-dihydroxy-
CAS REGISTRY NUMBER :
32476-67-8
LAST UPDATED :
199304
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C30-H46-O8
MOLECULAR WEIGHT :
534.76
WISWESSER LINE NOTATION :
L E5 B666TJ A1 E1 IQ MQ F- DT5OV EHJ& OO- FT6OTJ B1 CQ DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
155 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 74,223,1942

Chemsrc provides CAS#:32476-67-8 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 32476-67-8 | Chemsrc address: https://www.chemsrc.com/en/baike/28249.html

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