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80404-23-5

80404-23-5 structure
80404-23-5 structure
  • Name: Apocynin-d3
  • Chemical Name: 1-[4-hydroxy-2-(trideuteriomethoxy)phenyl]ethanone
  • CAS Number: 80404-23-5
  • Molecular Formula: C9H10O3
  • Molecular Weight: 166.17400
  • Catalog: Signaling Pathways Apoptosis Apoptosis
  • Create Date: 2016-06-22 08:03:33
  • Modify Date: 2024-01-06 18:41:22
  • Apocynin-d3 is the deuterium labeled Apocynin[1]. Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[2][3][4].
Name 1-[4-hydroxy-2-(trideuteriomethoxy)phenyl]ethanone
Synonyms Acetoguaiacon-d3
Apocynine-d3
1-(4-hydroxy-3-(d3)methoxyphenyl)ethanone
Acetoguaicone-d3
2-Methoxy-4-acetylphenol-d3
Acetovanillone-d3
4-Acetyl-2-methoxyphenol-d3
Apocynin-d3
4-Acetylguaiacol-d3
Acetoguaiacone-d3
Description Apocynin-d3 is the deuterium labeled Apocynin[1]. Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[2][3][4].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Stolk J,et al. Am J Respir Cell Mol Biol, 1994, 11(1), 95-102.  

[3]. Stefanska J, et al. Mediators Inflamm, 2008, 106507.  

[4]. Impellizzeri D et al. Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochem Pharmacol. 2011 Mar 181(5):636-48.  

Molecular Formula C9H10O3
Molecular Weight 166.17400
Exact Mass 166.06300
PSA 46.53000
LogP 1.60340
80404-22-4 structure

80404-22-4

~22%

80404-23-5 structure

80404-23-5

Literature: CONCERT PHARMACEUTICALS INC. Patent: US2008/255194 A1, 2008 ; Location in patent: Page/Page column 12 ; US 20080255194 A1
Precursor  1

DownStream  0


Chemsrc provides CAS#:80404-23-5 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 80404-23-5 | Chemsrc address: https://www.chemsrc.com/en/baike/284415.html

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