148396-36-5

148396-36-5 structure

Name: Fradafiban
Chemical Name: 2-[(3S,5S)-5-[[4-(4-carbamimidoylphenyl)phenoxy]methyl]-2-oxopyrrolidin-3-yl]acetic acid
CAS Number: 148396-36-5
Molecular Formula: C₂₀H₂₁N₃O₄
Molecular Weight: 367.39800
Catalog: Signaling Pathways Cytoskeleton Integrin
Create Date: 2018-07-14 08:49:24
Modify Date: 2024-02-12 13:29:43
Fradafiban is a nonpeptide platelet glycoprotein IIb/IIIa antagonist, which binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM.

Name	2-[(3S,5S)-5-[[4-(4-carbamimidoylphenyl)phenoxy]methyl]-2-oxopyrrolidin-3-yl]acetic acid
Synonyms	UNII-DQ0H2B8YKN C20H21N3O4 fradafibanum Fradafiban

Description	Fradafiban is a nonpeptide platelet glycoprotein IIb/IIIa antagonist, which binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM.
Related Catalog	Signaling Pathways >> Cytoskeleton >> Integrin Research Areas >> Cardiovascular Disease
Target	Kd: 148 nM (human platelet GP IIb/IIIa complex)[1]
In Vitro	Fradafiban is a nonpeptide mimetic of the arginine-glycine-aspartic acid recognition sequence. Fradafiban binds with high affinity and selectivity to the human platelet GP IIb/IIIa complex and potently inhibits human platelet aggregation in vitro. Fradafiban reversibly binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM[1].
In Vivo	Fradafiban has only very limited oral activity probably due to its high polarity and thus poor absorption after oral ingestion[1].
References	[1]. Müller TH, et al. Profound and sustained inhibition of platelet aggregation by Fradafiban, a nonpeptide platelet glycoprotein IIb/IIIa antagonist, and its orally active prodrug, Lefradafiban, in men. Circulation. 1997 Aug 19;96(4):1130-8.