881001-19-0

881001-19-0 structure

Name: HDS 029
Chemical Name: N-[4-(3-chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]but-2-ynamide
CAS Number: 881001-19-0
Molecular Formula: C₁₇H₁₁ClFN₅O
Molecular Weight: 355.75400
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2017-08-07 22:35:17
Modify Date: 2024-01-24 08:23:10
EGFR/ErbB-2/ErbB-4 inhibitor-3 (compound 29) is a potent tyrosine kinase inhibitor with IC50s of 0.3, 1.1, 0.5, 2.5, 24 nM for erbB1, erbB2, erbB4, EGF, HER, respectively[1].

Name	N-[4-(3-chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]but-2-ynamide
Synonyms	HMS3229E05 EGFR/ErbB-2/ErbB-4 Inhibitor IN1346 HDS 029

Description	EGFR/ErbB-2/ErbB-4 inhibitor-3 (compound 29) is a potent tyrosine kinase inhibitor with IC50s of 0.3, 1.1, 0.5, 2.5, 24 nM for erbB1, erbB2, erbB4, EGF, HER, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	ErbB2:1.1 nM (IC50) ErbB1:0.3 nM (IC50) ErbB4:0.5 nM (IC50) EGFR:2.5 nM (IC50) HER:24 nM (IC50)
References	[1]. Klutchko SR, et al. Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors. J Med Chem. 2006 Feb 23;49(4):1475-85.