Shanghai Nianxing Industrial Co., Ltd
China
Product Name: DiprotinA
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GL Biochem (Shanghai) Ltd.
China
Product Name: Diprotin A
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Diprotin A
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DC Chemicals Limited
China
Product Name: Diprotin A
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Diprotin a
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Purity: 98.0%
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90614-48-5

90614-48-5 structure

90614-48-5 structure

Name: Diprotin A
Chemical Name: diprotin a
CAS Number: 90614-48-5
Molecular Formula: C₁₇H₃₁N₃O₄
Molecular Weight: 341.44600
Catalog: Signaling Pathways Metabolic Enzyme/Protease Dipeptidyl Peptidase
Create Date: 2018-02-21 08:00:00
Modify Date: 2024-01-03 12:20:15
Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV)[1].

Name	diprotin a
Synonyms	MFCD00038707 H-ILE-PRO-ILE-OH ILE-PRO-ILE H2O Ile-Pro-Ile-OH H-ILE-PRO-ILE-OH H2O DIPEPTIDYLPEPTIDASE IV INHIBITOR I L-Isoleucyl-L-prolyl-L-isoleucine ILE-PRO-ILE L-Ile-L-Pro-L-Ile-OH

Description	Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV)[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase Research Areas >> Metabolic Disease
Target	IC50: DPP-IV[1]
In Vitro	Diprotin A (100 μM; 30 minutes after CXCR4-blocker or Src-inhibitor treatment) induces the phosphorylation of Src [Tyr 416] and VE-cadherin [Tyr731] in hECs in both normoxia and H/R conditions in human endothelial cells and disrupts endothelial cell-to-cell junctions, which are attenuated by CXCR4 (receptor of SDF-1α)-blocker or Src-inhibitor[1]. Western Blot Analysis[1] Cell Line: Human endothelial cells[1] Concentration: 100 μM Incubation Time: 30 minutes after CXCR4-blocker or Src-inhibitor treatment Result: Induced the phosphorylation of Src [Tyr 416] and VE-cadherin [Tyr731] in hECs.
In Vivo	Diprotin A (intraperitoneal injection; 70 μg/kg; twice daily; 7 days) increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway[1]. Animal Model: Streptozotocin-induced diabetic retinopathy model in wild-type C57/BL6 mice[1] Dosage: 70 μg/kg Administration: Intraperitoneal injection; twice daily; 7 days Result: Induced vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway.
References	[1]. Lee CS, et al. Dipeptidyl Peptidase-4 Inhibitor Increases Vascular Leakage in Retina through VE-cadherin Phosphorylation. Sci Rep. 2016 Jul 6;6:29393.

Density	1.14 g/cm3
Boiling Point	583.1ºC at 760 mmHg
Molecular Formula	C₁₇H₃₁N₃O₄
Molecular Weight	341.44600
Flash Point	306.5ºC
Exact Mass	341.23100
PSA	112.73000
LogP	1.99540
Index of Refraction	1.517
Storage condition	−20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NR4737000

CHEMICAL NAME :: L-Isoleucine, N-(1-L-isoleucyl-L-prolyl)-

CAS REGISTRY NUMBER :: 90614-48-5

LAST UPDATED :: 199212

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C17-H31-N3-O4

MOLECULAR WEIGHT :: 341.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 37,422,1984

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	NR4737000