200006-08-2

200006-08-2 structure

Name: ALX 5407 hydrochloride
Chemical Name: 2-[[(3R)-3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl]-methylamino]acetic acid,hydrochloride
CAS Number: 200006-08-2
Molecular Formula: C₂₄H₂₅ClFNO₃
Molecular Weight: 429.91200
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GlyT
Create Date: 2016-11-11 21:52:44
Modify Date: 2024-01-10 16:26:58
ALX-5407 ((R)-NFPS) hydrochloride is a selective and orally active glycine transporter GlyT1 inhibitor with an IC50 value of 3 nM. ALX-5407 hydrochloride can be used the research of N-methyl-D-aspartate-receptor function and schizophrenia[1].

Name	2-[[(3R)-3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl]-methylamino]acetic acid,hydrochloride
Synonyms	N-[(3R)-3-([1,1'-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine Hydrochloride ALX 5407 hydrochloride 187-1,N-WASP inhibitor N-[3-(4'-Fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine hydrochloride (+/-)-NFPS hydrochloride

Description	ALX-5407 ((R)-NFPS) hydrochloride is a selective and orally active glycine transporter GlyT1 inhibitor with an IC50 value of 3 nM. ALX-5407 hydrochloride can be used the research of N-methyl-D-aspartate-receptor function and schizophrenia[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GlyT Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GlyT
In Vitro	ALX-5407 hydrochloride (0-1 mM) GlyT1- 或 GlyT2- 依赖地抑制甘氨酸转运，阻断大鼠大脑和 QT6-1C 细胞中 [3H] 甘氨酸的摄取，IC50 值为 3 nM[1]。 ALX-5407 hydrochloride (50 nM) 在 QT6-1C 细胞中表现出缓慢的解离动力学[1]。
In Vivo	ALX-5407 hydrochloride (1 和 10 mg/kg；口服，一次) 增加大鼠前额叶皮层游离甘氨酸水平[1]。
References	[1]. Atkinson BN, et al. ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter. Mol Pharmacol. 2001 Dec;60(6):1414-20.