3650-73-5
3650-73-5 structure
- Name: Homocarnosine
- Chemical Name: .γ.-Aminobutyryl-L-histidine
- CAS Number: 3650-73-5
- Molecular Formula: C10H16N4O3
- Molecular Weight: 240.25900
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
- Create Date: 2018-06-18 00:48:22
- Modify Date: 2024-01-10 13:40:40
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Homocarnosine is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects[1].Homocarnosine has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation[2].
| Name | .γ.-Aminobutyryl-L-histidine |
|---|---|
| Synonyms |
L-homocarnosine
<4-Amino-butyryl>-L-histidin,Homocarnosin L-HOMOCARNOSINE FREE BASE |
| Description | Homocarnosine is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects[1].Homocarnosine has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation[2]. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | Homocarnosine, a dipeptide of γ-aminobutyric acid (GABA) and histidine, is an inhibitory neuromodulator synthesized in subclasses of GABAergic neurons[1].Homocarnosine is a potent alternative imidazole peptide for skeletal muscle based on its structural similarity to Carnosine. Homocarnosine is composed of γ-aminobutyric acid (GABA) and histidine and has a similar structure to Carnosine, with the only difference being an extra carbon atom in GABA compared to that in β-alanine of carnosine. Homocarnosine possesses greater tolerance to degradation by serum carnosinase relative to Carnosine. Homocarnosine is known to be exclusively present in brain and cerebrospinal fluid and acts as a neuroprotective agent in a broad range of disease conditions. Homocarnosine exerts antioxidant activity and prevent DNA oxidative damage to a similar extent as Carnosine[2]. |
| References |
| Boiling Point | 646.9ºC at 760mmHg |
|---|---|
| Molecular Formula | C10H16N4O3 |
| Molecular Weight | 240.25900 |
| Flash Point | 345.1ºC |
| Exact Mass | 240.12200 |
| PSA | 121.10000 |
| LogP | 0.35170 |
| Index of Refraction | 1.579 |
| WGK Germany | 3 |
|---|---|
| HS Code | 2933290090 |
| HS Code | 2933290090 |
|---|---|
| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |