1184136-10-4
1184136-10-4 structure
- Name: UNC-926
- Chemical Name: (3-bromophenyl)-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone
- CAS Number: 1184136-10-4
- Molecular Formula: C16H21BrN2O
- Molecular Weight: 337.25500
- Catalog: Research Areas Cancer
- Create Date: 2018-06-17 17:39:25
- Modify Date: 2024-01-09 21:28:00
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UNC-926 is a methyl-lysine (Kme) reader domain inhibitor; inhibits L3MBTL1 with an IC50 of 3.9 μM.
| Name | (3-bromophenyl)-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone |
|---|---|
| Synonyms |
UNC 926 hydrochloride
UNC-926 |
| Description | UNC-926 is a methyl-lysine (Kme) reader domain inhibitor; inhibits L3MBTL1 with an IC50 of 3.9 μM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 3.9 μM (L3MBTL1)[1] |
| In Vitro | UNC-926 inhibits L3MBTL1 with an IC50 of 3.9 μM. L3MBTL1UNC-926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3, with a decrease in affinity for the other MBT domains and no binding to CBX7. UNC-926 inhibits binding of the 3xMBT domain to H4K20me1. It selectively inhibits the L3MBTL13xMBT-H4K20me1 interaction in a dose-dependent manner. UNC-926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC-926 for L3MBTL1 over 53BP1[1]. |
| References |
| Molecular Formula | C16H21BrN2O |
|---|---|
| Molecular Weight | 337.25500 |
| Exact Mass | 336.08400 |
| PSA | 23.55000 |
| LogP | 3.02530 |
| Storage condition | -20℃ |
| RIDADR | NONH for all modes of transport |
|---|