27409-30-9

27409-30-9 structure

Name: Picroside I
Chemical Name: picroside i
CAS Number: 27409-30-9
Molecular Formula: C₂₄H₂₈O₁₁
Molecular Weight: 492.473
Catalog: Biochemical Plant extracts
Create Date: 2018-04-20 08:00:00
Modify Date: 2024-01-02 16:46:55
Picroside I is the major ingredient of Picrorhiza kurroa. Picrorhiza kurroa is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II[1]. Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ[2].

Name	picroside i
Synonyms	picroside-1 PicrosideI 2-Propenoic acid, 3-phenyl-, (1aS,1bS,2S,5aR,6S,6aS)-2-(β-D-glucopyranosyloxy)-1a,1b,2,5a,6,6a-hexahydro-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-6-yl ester, (2E)- β-D-Glucopyranoside, (1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl 6-O-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]- 6'-O-trans-cinnamoylcatalpol (1aS,1bS,2S,5aR,6S,6aS)-6-Hydroxy-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[4,5]cyclopenta[1,2-c]pyran-2-yl 6-O-[(2E)-3-phenyl-2-propenoyl]-β-D-glucopyranoside picrosides I Picroside I (1aS,1bS,2S,5aR,6S,6aS)-2-(β-D-Glucopyranosyloxy)-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[4,5]cyclopenta[1,2-c]pyran-6-yl (2E)-3-phenylacrylate

Description	Picroside I is the major ingredient of Picrorhiza kurroa. Picrorhiza kurroa is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II[1]. Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ[2].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Signaling Pathways >> JAK/STAT Signaling >> STAT Research Areas >> Inflammation/Immunology
Target	STAT6
References	[1]. Ganeshkumar Y, et al. Picroside I and Picroside II from Tissue Cultures of Picrorhiza kurroa. Pharmacognosy Res. 2017 Dec;9(Suppl 1):S53-S56. [2]. Sen Zhang, et al. Picroside I inhibits asthma phenotypes by regulating Tbet/GATA-3 ratio and Th1/Th2 balance in a murine model of asthma. Tropical Journal of Pharmaceutical Research September 2018; 17 (9): 1777-1782.

Density	1.6±0.1 g/cm3
Boiling Point	739.1±60.0 °C at 760 mmHg
Melting Point	130 °C
Molecular Formula	C₂₄H₂₈O₁₁
Molecular Weight	492.473
Flash Point	253.2±26.4 °C
Exact Mass	492.163147
PSA	167.67000
LogP	-1.81
Vapour Pressure	0.0±2.6 mmHg at 25°C
Index of Refraction	1.671
Storage condition	2-8°C
Water Solubility	ethanol: soluble1mg/mL, clear, colorless

Hazard Codes	Xi
Safety Phrases	24/25
RIDADR	NONH for all modes of transport
HS Code	29389090