125441-00-1

125441-00-1 structure

Name: Acetyl-Hirudin (54-65) (sulfated)
Chemical Name: Acetyl-Hirudin (54-65) (sulfated)
CAS Number: 125441-00-1
Molecular Formula: C₆₈H₉₅N₁₃O₂₉S
Molecular Weight: 1590.617
Catalog: Research Areas Metabolic Disease
Create Date: 2016-04-12 07:38:55
Modify Date: 2024-01-10 16:07:38
Acetyl-Hirudin (54-65) (sulfated) binds directly to thrombin-rHCII(L444R) and disrupts interactions between the N-terminal acidic domain of rHCII and anion-binding exosite I of thrombin that serves to stabilize the complex[1].

Name	Acetyl-Hirudin (54-65) (sulfated)
Synonyms	Glutamine, N-acetylglycyl-α-aspartylphenylalanyl-α-glutamyl-α-glutamylisoleucylprolyl-α-glutamyl-α-glutamyl-O-sulfotyrosylleucyl- N-ACETYL-HIRUDIN AC-[TYR(SO3H)63]-FRAGMENT 54-65 acetyl-[tyr(so3h)63]-hirudin fragment 54-65 N-Acetylglycyl-α-aspartylphenylalanyl-α-glutamyl-α-glutamylisoleucylprolyl-α-glutamyl-α-glutamyl-O-sulfotyrosylleucylglutamine AC-GLY-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-GLN-OH AC-GLY-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-GLN N-acetyl-(tyr(so3H)63)-hirudin *fragment 54-65 ACETYL-GLY-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR[SO3H]-LEU-GLN AC-HIRUDIN (54-65) (SULFATED)

Description	Acetyl-Hirudin (54-65) (sulfated) binds directly to thrombin-rHCII(L444R) and disrupts interactions between the N-terminal acidic domain of rHCII and anion-binding exosite I of thrombin that serves to stabilize the complex[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
References	[1]. J H Han, et al. Heparin facilitates dissociation of complexes between thrombin and a reactive site mutant (L444R) of heparin cofactor II. J Biol Chem. 1997 Mar 28;272(13):8243-9.