Taiwan Oyi peptide Co. Ltd
China
Product Name: BIG ENDOTHELIN-1 FRAGMENT (22-38) (HUMAN)
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Purity: 98.0%
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124932-61-2

124932-61-2 structure

Name: Big Endothelin-1 (22-38), human
Chemical Name: Big Endothelin-1: 22-38, human
CAS Number: 124932-61-2
Molecular Formula: C₈₀H₁₂₅N₂₃O₂₅
Molecular Weight: 1808.99000
Catalog: Research Areas Cardiovascular Disease
Create Date: 2018-12-10 18:51:45
Modify Date: 2024-01-07 16:42:33
Big Endothelin-1 (22-38), human is derived from human, is the 22-38 fragment of Big Endothelin-1 (ET-1) (1-38). Big ET-1 (1-38) is a propeptide of ET-1, which has potent and long-lasting vasoconstrictor effects, equips a specific enzymatic cleavage of the 38 amino acid chain to form ET-1 (1-21) and the C-terminal fragment Big ET-1 (22-38)[1].

Name	Big Endothelin-1: 22-38, human

Description	Big Endothelin-1 (22-38), human is derived from human, is the 22-38 fragment of Big Endothelin-1 (ET-1) (1-38). Big ET-1 (1-38) is a propeptide of ET-1, which has potent and long-lasting vasoconstrictor effects, equips a specific enzymatic cleavage of the 38 amino acid chain to form ET-1 (1-21) and the C-terminal fragment Big ET-1 (22-38)[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
In Vitro	Big Endothelin-1 (22-38), human (0.1 μM; 30 min) induces the release of prostacyclin (PGI2) from rabbit, guinea pig, and rat lungs[2].
In Vivo	Big Endothelin-1 (22-38), human (3 nM/kg; intra-arterial injection; single dose) produces a significant rise in left ventricular systolic pressure (LVSP) in anesthetized rabbits, and is enhanced by cyclooxygenase inhibitor Indomethacin (HY-14397) (5 mg/kg i.v.) significantly[3]. Big Endothelin-1 (22-38), human (3 nM/kg; intravascular method; single dose), has no antiaggregatory properties for platelet induced by ADP in rabbits[3].
References	[1]. Hemsén A, et al. Metabolism of Big endothelin-1 (1-38) and (22-38) in the human circulation in relation to production of endothelin-1 (1-21). Regul Pept. 1995 Feb 14;55(3):287-97. [2]. D'Orléans-Juste P, et al. Human big endothelin releases prostacyclin in vivo and in vitro through a phosphoramidon-sensitive conversion to endothelin-1. J Cardiovasc Pharmacol. 1991;17 Suppl 7:S251-5. [3]. Huneidi AH, et al. Endothelin-1 and big endothelin cause subarachnoid hemorrhage in the anesthetized rabbit. J Cardiovasc Pharmacol. 1991;17 Suppl 7:S492-5.

Molecular Formula	C₈₀H₁₂₅N₂₃O₂₅
Molecular Weight	1808.99000
Exact Mass	1807.92000
PSA	754.44000

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