Shanghai Nianxing Industrial Co., Ltd
China
Product Name: medroxyprogesterone
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DC Chemicals Limited
China
Product Name: Medroxyprogesterone
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Medroxyprogesterone
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Purity: 98.0%
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520-85-4

520-85-4 structure

Name: medroxyprogesterone
Chemical Name: medroxyprogesterone
CAS Number: 520-85-4
Molecular Formula: C₂₂H₃₂O₃
Molecular Weight: 344.488
Catalog: analytical chemistry Analytical reagent Ion chromatography reagent
Create Date: 2018-04-08 08:00:00
Modify Date: 2024-01-02 08:30:44
Medroxyprogesterone is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.Target: Progesterone ReceptorMedroxyprogesterone (MP), is a steroidal progestin drug which was never marketed for use in humans. An acylated derivative, medroxyprogesterone acetate (MPA), is clinically used as a pharmaceutical medicine. Compared to MPA, MP is over two orders of magnitude less potent as a progestogen. As such, MP itself is not used clinically, though it has seen limited use in veterinary medicine under the trade name Controlestril in France. In addition, it is an metabolite of MPA [1].

Name	medroxyprogesterone
Synonyms	Medroxyprogesteron Medroxyprogesteronum Hydroxymethylprogesterone MFCD00069474 17α-Hydroxy-6α-methylprogesterone Medroxy Progesterone 17-Hydroxy-6α-methylprogesterone Medrossiprogesterone 17alpha-Hydroxy-6alpha-methylprogesterone (6a)-17-Hydroxy-6-methylpregn-4-ene-3,20-dione 17-Hydroxy-6a-methylprogesterone Medroxiprogesterone 17a-Hydroxy-6a-methylprogesterone 17-Hydroxy-6alpha-methylprogesterone 6a-Methyl-17a-hydroxyprogesterone 6α-Methyl-17α-hydroxyprogesterone Farlutal 17α-Hydroxy-6α-methylpregn-4-ene-3,20-dione EINECS 208-298-6 (6α)-17-Hydroxy-6-methylpregn-4-ene-3,20-dione Pregn-4-ene-3,20-dione, 17-hydroxy-6α-methyl- medroxyprogesterone (6S,8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one Pregn-4-ene-3,20-dione, 17-hydroxy-6-methyl-, (6α)- Medroxiprogesteronum Pregn-4-ene-3,20-dione, 17α-hydroxy-6α-methyl- Medroxyprogesterone Base

Description	Medroxyprogesterone is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.Target: Progesterone ReceptorMedroxyprogesterone (MP), is a steroidal progestin drug which was never marketed for use in humans. An acylated derivative, medroxyprogesterone acetate (MPA), is clinically used as a pharmaceutical medicine. Compared to MPA, MP is over two orders of magnitude less potent as a progestogen. As such, MP itself is not used clinically, though it has seen limited use in veterinary medicine under the trade name Controlestril in France. In addition, it is an metabolite of MPA [1].
Related Catalog	Signaling Pathways >> Others >> Progesterone Receptor Research Areas >> Endocrinology
References	[1]. http://en.wikipedia.org/wiki/Medroxyprogesterone

Density	1.1±0.1 g/cm3
Boiling Point	488.0±45.0 °C at 760 mmHg
Melting Point	220-223.5ºC
Molecular Formula	C₂₂H₃₂O₃
Molecular Weight	344.488
Flash Point	263.0±25.2 °C
Exact Mass	344.235138
PSA	54.37000
LogP	3.38
Vapour Pressure	0.0±2.8 mmHg at 25°C
Index of Refraction	1.554
Storage condition	Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU5300000

CHEMICAL NAME :: Pregn-4-ene-3,20-dione, 17-hydroxy-6-alpha-methyl-

CAS REGISTRY NUMBER :: 520-85-4

BEILSTEIN REFERENCE NO. :: 2510965

LAST UPDATED :: 199706

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C22-H32-O3

MOLECULAR WEIGHT :: 344.54

WISWESSER LINE NOTATION :: L E5 B666 OV MUTJ A1 E1 FV1 FQ K1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 6 mg/kg/13W-I

TOXIC EFFECTS :: Peripheral Nerve and Sensation - sensory change involving peripheral nerve Behavioral - hallucinations, distorted perceptions Lungs, Thorax, or Respiration - other changes

REFERENCE :: MJAUAJ Medical Journal of Australia. (Australasian Medical Pub. Co. Ltd., 71-79 Arundel St., Glebe, N.S.W., Australia) V.1- 1914- Volume(issue)/page/year: 163,51,1995 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 20 mg/kg

SEX/DURATION :: female 17-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: ECJPAE Endocrinologia Japonica. (Japan Pub. Trading Co., Ltd., POB 5030, Tokyo International, Tokyo, Japan) V.1- 1954- Volume(issue)/page/year: 24,77,1977

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 625 mg/kg

SEX/DURATION :: female 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 12,445,1966

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1120 mg/kg

SEX/DURATION :: male 16 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08- Volume(issue)/page/year: 187,431,1977

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 5 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: 85GRAA "The Control of Fertility," Pincus, G., New York, Academic Press, 1965 Volume(issue)/page/year: -,57,1965 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7306 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 339 (estimated) No. of Female Employees: 170 (estimated)

Symbol	GHS08
Signal Word	Warning
Hazard Statements	H361
Precautionary Statements	P280
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	Xn
Risk Phrases	48-63-68
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TU5300000

Precursor 6
113665-92-2 3386-01-4 3386-00-3 3496-78-4
80996-18-5 1863-39-4
DownStream 3
3562-63-8 595-33-5 71-58-9

520-85-4	162462-69-3
71-58-9	135843-32-2
6947-47-3	78261-67-3
6678-23-5	1158522-08-7
940364-43-2	134104-43-1
131615-57-1	2366182-84-3
2059945-27-4	6906-52-1
930439-75-1	1018584-77-4
1375289-11-4