Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Auramine O
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Auramine O
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DC Chemicals Limited
China
Product Name: Auramine hydrochloride
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Basic Yellow 2
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: AURAMINE O
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2465-27-2

2465-27-2 structure

Name: Auramine O
Chemical Name: auramine O
CAS Number: 2465-27-2
Molecular Formula: C₁₇H₂₂ClN₃
Molecular Weight: 303.830
Catalog: Dyes and pigments dye Basic dye
Create Date: 2018-04-29 08:00:00
Modify Date: 2024-01-02 23:40:47
Auramine O is a yellow fluorescent dye and can be used to stain acid-fast bacteria. Auramine O is toxic and resistant in the environment[1][2].

Name	auramine O
Synonyms	Hydrogen chloride - 4,4'-carbonimidoylbis(N,N-dimethylaniline) (1:1:1) Auramine Extra Auramine O [Dye Content Basic Yellow 2 MFCD00012484 Auramine Pure Auramine N Auramine O Benzenamine, 4,4'-carbonimidoylbis[N,N-dimethyl-, chloride, hydrogen salt (1:1) AURAMINE HYDROCHLORIDE Aizen auramine EINECS 219-567-2 Pyoctaninum aureum AURAMINE Benzenamine, 4,4'-carbonimidoylbis[N,N-dimethyl-, monohydrochloride 4,4′-(Imidocarbonyl)bis(N,N-dimethylaniline) monohydrochloride 4-[4-(dimethylamino)benzenecarboximidoyl]-N,N-dimethylaniline,hydrochloride C.I. Basic Yellow 2 Auramine Yellow Auramine O,biological stain CI Basic Yellow 2 Auramin

Description	Auramine O is a yellow fluorescent dye and can be used to stain acid-fast bacteria. Auramine O is toxic and resistant in the environment[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Kommareddi S, et al. Nontuberculous mycobacterial infections: comparison of the fluorescent auramine-O and Ziehl-Neelsen techniques in tissue diagnosis. Hum Pathol. 1984 Nov;15(11):1085-9. [2]. Hosseinpour S A, et al. Use of metal composite MOF‐5‐Ag2O‐NPs as an adsorbent for the removal of Auramine O dye under ultrasound energy conditions. Applied Organometallic Chemistry, 2018, 32(2): e4007.

Density	1.01g/cm3
Boiling Point	406.2ºC at 760mmHg
Melting Point	>250 °C (dec.)(lit.)
Molecular Formula	C₁₇H₂₂ClN₃
Molecular Weight	303.830
Flash Point	199.4ºC
Exact Mass	303.150238
PSA	30.33000
LogP	4.13650
Vapour Pressure	8.31E-07mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BY3675000

CHEMICAL NAME :: Aniline, 4,4'-(imidocarbonyl)bis(N,N-dimethyl-, hydrochloride

CAS REGISTRY NUMBER :: 2465-27-2

LAST UPDATED :: 199710

DATA ITEMS CITED :: 32

MOLECULAR FORMULA :: C17-H21-N3.Cl-H

MOLECULAR WEIGHT :: 303.87

WISWESSER LINE NOTATION :: 1N1&R DYUM&R DN1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 135 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 40 gm/kg/87W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 440 mg/kg/21W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 73 gm/kg/52W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 32760 mg/kg/39W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: Morphological transformation

TYPE OF TEST :: DNA damage

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 20 umol/L/5H (Continuous)

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FRANCE;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1444 No. of Facilities: 1184 (estimated) No. of Industries: 17 No. of Occupations: 22 No. of Employees: 10114 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1444 No. of Facilities: 1191 (estimated) No. of Industries: 27 No. of Occupations: 24 No. of Employees: 19092 (estimated) No. of Female Employees: 4705 (estimated)

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H302-H311-H351
Precautionary Statements	P280-P312
Hazard Codes	T:Toxic
Risk Phrases	R22;R24;R40
Safety Phrases	S36/37-S45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	BY3675000
Hazard Class	6.1
HS Code	2925290090

HS Code	2925290090
Summary	2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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