611-36-9

611-36-9 structure

Name: 4-quinolone
Chemical Name: quinolin-4-ol
CAS Number: 611-36-9
Molecular Formula: C₉H₇NO
Molecular Weight: 145.158
Catalog: Pharmaceutical intermediate Heterocyclic compound Quinoline compound
Create Date: 2018-07-20 00:25:54
Modify Date: 2024-01-02 13:14:07
4-Quinolone (Kynurine) is a quinoline derivative. Kynurine pathway modulates tryptophan metabolism and involves in neuroprotective effect. Kynurine promotes tumor cell survival and motility by suppressing antitumor immune[1][2].

Name	quinolin-4-ol
Synonyms	4-Quinolinol Chinolin-4-ol p-hydroxyquinoline 4-quinolone 4(1H)-QUINOLINONE Chinolin-4(1H)-on Quinolin-4(1H)-one quinolin-4-one 1,4-Dihydroquinoline-4-one HYDROXYQUINOLINE,4 4-hydroxyquinoline acid KYNURINE 4-Hydroxyquinoline 4-oxo-1,4-dihydroquinoline 4-hydroxy-quinolin EINECS 210-268-2 quinolin-4-ol quinoline-4-ol MFCD00006777

Description	4-Quinolone (Kynurine) is a quinoline derivative. Kynurine pathway modulates tryptophan metabolism and involves in neuroprotective effect. Kynurine promotes tumor cell survival and motility by suppressing antitumor immune[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Neurological Disease
In Vitro	4-Quinolone (Kynurine) promotes tumor cell survival and motility by suppressing antitumor immune responses through AhR in an autocrine/paracrine fashion. This system is particularly active in human brain tumors where the activation of AhR enhances the expression of TDO producing more kynurine and kynurinic acid. In the healthy human brain, very low levels of TDO exist, whereas, in human brain tumors, the TDO protein levels increase with malignancy[3].
References	[1]. Pellicciari R, et al. Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase. Adv Exp Med Biol. 2003;527:621-8. [2]. Marija Pinne, et al. Cytochrome P450 Gene Regulation: Reporter Assays to Assess Aryl Hydrocarbon Receptor (HLHE76, AhR) Activation and Antagonism. Cytochrome P450. pp 157-174. [3]. Opitz CA, et al. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature. 2011 Oct 5;478(7368):197-203.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	VC4070000
HS Code	2933499090

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%