1955-67-5

1955-67-5 structure

Name: L-GlutaMic acid γ-MonohydroxaMate
Chemical Name: glutamine hydroxamate
CAS Number: 1955-67-5
Molecular Formula: C₅H₁₀N₂O₄
Molecular Weight: 162.14400
Catalog: Research Areas Cancer
Create Date: 2017-09-17 07:52:17
Modify Date: 2024-01-09 18:46:25
L-Glutamic γ-monohydroxamate is an antitumor agent, inhibits cell proliferation. L-Glutamic γ-monohydroxamate selectively inhibits the uptake of L-histidine into microvascular endothelial cell. L-Glutamic γ-monohydroxamate, as a vanadium ligand, activates glucose uptake and metabolism, thus decreases the blood glucose levels in vivo[1][2][3].

Name	glutamine hydroxamate
Synonyms	(4S)-4-Amino-4-carboxybutanehydroxamic acid (2S)-5-amino-2-(hydroxyamino)-5-keto-valeric acid N5-Hydroxy-L-glutamine (S)-4-Amino-4-carboxybutanehydroximic acid 3-[2-Oxo-2-(hydroxyamino)ethyl]alanine (2S)-2-Amino-5-oxo-5-(hydroxyamino)pentanoic acid AMINO ACID HYDROXAMATES L-GLUTAMIC ACID γ-MONOHYDROXAMATE L-GlutaMic acid γ-MonohydroxaMate

Description	L-Glutamic γ-monohydroxamate is an antitumor agent, inhibits cell proliferation. L-Glutamic γ-monohydroxamate selectively inhibits the uptake of L-histidine into microvascular endothelial cell. L-Glutamic γ-monohydroxamate, as a vanadium ligand, activates glucose uptake and metabolism, thus decreases the blood glucose levels in vivo[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
References	[1]. Vila J, et al. In vitro and in vivo anti-tumor activity of L-glutamic acid gamma-monohydroxamate against L1210 leukemia and B16 melanoma. Int J Cancer. 1990 Apr 15;45(4):737-43. [2]. Sakurai E, et al. Stereoselective transport of histidine in rat lung microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2002 Jun;282(6):L1192-7. [3]. Goldwaser I, et al. L-Glutamic acid gamma-monohydroxamate. A potentiator of vanadium-evoked glucose metabolism in vitro and in vivo. J Biol Chem. 1999 Sep 10;274(37):26617-24.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2928000090

142-47-2

1955-67-5

Literature: Yamamoto, Sachiko; Wakayama, Mamoru; Tachiki, Takashi Bioscience, Biotechnology and Biochemistry, 2007 , vol. 71, # 2 p. 545 - 552

10148-81-9

1955-67-5

1119-33-1

1955-67-5

Literature: Roper; McIlwain Biochemical Journal, 1948 , vol. 42, p. 488

3183-72-0

1955-67-5

56-12-2

Literature: Magnan, Sanne D. J.; Shirota, Frances N.; Nagasawa, Herbert T. Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1018 - 1021

56-86-0

1955-67-5

Literature: Roper; McIlwain Biochemical Journal, 1948 , vol. 42, p. 488

56-85-9

1955-67-5

70-18-8

1955-67-5

HS Code	2928000090
Summary	2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%