Name | 4-Phenoxybenzylamine |
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Synonyms |
(4-Phenoxyphenyl)methanamine
MFCD01310836 Benzenemethanamine, 4-phenoxy- 1-(4-Phenoxyphenyl)methanamine |
Description | 4-Phenoxybenzylamine inhibits the function of the NS3 protein by stabilizing an inactive conformation with an IC50 of about 500 μM against FL NS3/4a. |
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Related Catalog | |
Target |
IC50: 500 μM (FL NS3/4a)[1] |
In Vitro | A highly conserved novel binding site located at the interface between the protease and helicase domains of the Hepatitis C Virus (HCV) NS3 protein is identified. 4-Phenoxybenzylamine binding at this allosteric site inhibits the function of the NS3 protein by stabilizing an inactive conformation and thus represents a new class of direct acting antiviral agents[1]. |
References |
Density | 1.1±0.1 g/cm3 |
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Boiling Point | 319.6±25.0 °C at 760 mmHg |
Molecular Formula | C13H13NO |
Molecular Weight | 199.248 |
Flash Point | 149.5±16.4 °C |
Exact Mass | 199.099716 |
PSA | 35.25000 |
LogP | 3.08 |
Vapour Pressure | 0.0±0.7 mmHg at 25°C |
Index of Refraction | 1.595 |
Hazard Codes | C: Corrosive;Xi: Irritant; |
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Risk Phrases | R36/37/38 |
Safety Phrases | 26-36/37/39 |
HS Code | 2922299090 |
~45% 107622-80-0 |
Literature: Fotsch; Sonnenberg; Chen; Hale; Karbon; Norman Journal of Medicinal Chemistry, 2001 , vol. 44, # 14 p. 2344 - 2356 |
~% 107622-80-0 |
Literature: Journal of Medicinal Chemistry, , vol. 44, # 14 p. 2344 - 2356 |
~% 107622-80-0 |
Literature: Journal of Medicinal Chemistry, , vol. 44, # 14 p. 2344 - 2356 |
~% 107622-80-0 |
Literature: Bioorganic and Medicinal Chemistry, , vol. 17, # 4 p. 1428 - 1436 |
~% 107622-80-0 |
Literature: Pharmaceutical Bulletin, , vol. 5, p. 397,399 |
~% 107622-80-0 |
Literature: Pharmaceutical Bulletin, , vol. 5, p. 397,399 |
HS Code | 2922299090 |
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Summary | 2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |